204205-90-3
中文名稱
2-(1-(4-氯芐基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺
英文名稱
2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide
CAS
204205-90-3
分子式
C22H16ClN3O2
分子量
389.83
MOL 文件
204205-90-3.mol
更新日期
2024/12/23 17:38:58
204205-90-3 結(jié)構(gòu)式
基本信息
中文別名
2-溴-2-(2-氟苯基)-1-環(huán)丙乙酮2-(1-(4-氯芐基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺
英文別名
ZIO 301Indibulin
Nascapine
lindiblin
2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide
1H-Indole-3-acetamide, 1-[(4-chlorophenyl)methyl]-α-oxo-N-4-pyridinyl-
2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide
2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide
2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide ISO 9001：2015 REACH
所屬類別
醫(yī)藥中間體：芐基吡啶物理化學(xué)性質(zhì)
密度1.31±0.1 g/cm3(Predicted)
儲存條件Sealed in dry,Store in freezer, under -20°C
溶解度DMSO:33.25(Max Conc. mg/mL);85.29(Max Conc. mM)
酸度系數(shù)(pKa)9.38±0.70(Predicted)
形態(tài)固體
顏色Off-white to yellow
2-(1-(4-氯芐基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-13649 | 2-(1-(4-氯芐基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺 Indibulin | 204205-90-3 | 5mg | 700元 |
| 2024/11/08 | HY-13649 | 2-(1-(4-氯芐基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺 Indibulin | 204205-90-3 | 10mM * 1mLin DMSO | 770元 |
| 2024/11/08 | HY-13649 | 2-(1-(4-氯芐基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺 Indibulin | 204205-90-3 | 10mg | 1120元 |
常見問題列表
生物活性
Indibulin (ZIO 301, D 24851, Zybulin) 是一種口服的 tubulin assembly 抑制劑，并具有有效的抗癌活性。Indibulin 可誘導(dǎo)有絲分裂的停滯和凋亡。靶點(diǎn)
| Target | Value |
|
Tubulin
() |
體外研究
Indibulin (300-2100 nM; 48?hours) inhibits the proliferation of MCF-7 cells with an IC50 of 150?nM.
Indibulin (300, 600 nM; 48?hours) blockes the cells in the G2/M phase indicating that indibulin blockes the progression of the cell cycle at mitosis.
Indibulin (150-600 nM; 24?hours) induces apoptosis in MCF-7 cells.
Indibulin (150-600 nM; 48?hours) with 300 and 600?nM generates cleaved fragments of PARP protein the treatment of MCF-7 cells.
Cell Proliferation Assay
| Cell Line: | MCF-7 cells |
| Concentration: | 300, 600, 900, 1200, 1500, 1800, 2100 nM |
| Incubation Time: | 48?hours |
| Result: | Inhibited the proliferation of MCF-7 cells with an IC 50 of 150?nM. |
Cell Cycle Analysis
| Cell Line: | MCF-7 cells |
| Concentration: | 300, 600 nM |
| Incubation Time: | 48?hours |
| Result: | Blocked the cells in the G2/M phase of the cell cycle. |
Apoptosis Analysis
| Cell Line: | MCF-7 cells |
| Concentration: | 150, 300 and 600?nM |
| Incubation Time: | 24?hours |
| Result: | Induced apoptosis in MCF-7 cells. |
Western Blot Analysis
| Cell Line: | MCF-7 cells |
| Concentration: | 150, 300 and 600?nM |
| Incubation Time: | 48?hours |
| Result: | Generated cleaved fragments of PARP protein in 300 and 600?nM. |