199433-58-4
199433-58-4 結(jié)構(gòu)式
基本信息
Y 39983
Y39983
Y33075
Y 39983
(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide
4-[(1R)-1-Aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide
Benzamide, 4-[(1R)-1-aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-yl-
(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide ISO 9001：2015 REACH
物理化學(xué)性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/08 | HY-10067 | (R)-4-(1-氨基乙基)-N-1H-吡咯并[2,3-B]吡啶-4-基苯甲酰胺 Y-33075 | 199433-58-4 | 1 mg | 726元 |
| 2025/02/08 | HY-10067 | (R)-4-(1-氨基乙基)-N-1H-吡咯并[2,3-B]吡啶-4-基苯甲酰胺 Y-33075 | 199433-58-4 | 5 mg | 1598元 |
| 2025/02/08 | HY-10067 | (R)-4-(1-氨基乙基)-N-1H-吡咯并[2,3-B]吡啶-4-基苯甲酰胺 Y-33075 | 199433-58-4 | 10mg | 2558元 |
常見問題列表
|
ROCK 3.6 nM (IC 50 ) |
PKC 420 nM (IC 50 ) |
CaMKII 810 nM (IC 50 ) |
Y-33075 (Y-39983) is a potent ROCK inhibitor, with an IC 50 of 3.6 nM. Y-33075 also inhibits PKC and CaMKII more potently than Y-27632, and the IC 50 s of Y-27632 and Y-33075 for PKC are 9.0 μM and 0.42 μM, respectively, whereas the IC 50 s of Y-27632 and Y-33075 for CaMKII are 26 μM and 0.81 μM, respectively. The IC 50 s of Y-27632 and Y-33075 for PKC is 82 and 117 times those for ROCK, respectively, whereas the IC 50 s of Y-27632 and Y-33075 for CaMKII is 236 and 225 times those for ROCK, respectively. Y-33075 (Y-39983, 10 μM) extends neurites in the retinal ganglion cells (RGCs) compared with those in RGCs treated without Y-39983. Y-33075 (Y-39983, 1 μM) inhibits the contraction of rabbit ciliary artery segments evoked by histamine in Ca 2+ -free solutions. Y-33075 (10 μM) shows no effect on the [Ca 2+ ]i increase with the high-potassium (high-K) solution.
In rabbits, Y-39983 (≥0.01%) significantly lowers intraocular pressure (IOP) at 2 hours after topical administration. In monkeys, Y-39983 (0.05%)-treated eyes show significant reduction of IOP between 2 and 7 hours after topical administration. Y-39983 (100 μM) increases the regenerating axons of retinal ganglion cells (RGCs) in the eyes of the rats.