146986-50-7
146986-50-7 結(jié)構(gòu)式
基本信息
ROCK-I和ROCK-II抑制劑
ROCK抑制劑(AZAINDOLE1)
ROCK-I和ROCK-II抑制劑(Y-27632)
反式-4-(R-1-氨基乙基)-N-(吡啶-4-基)環(huán)己烷甲酰胺
4-[(1R)-1-氨基乙基]-N-(吡啶-4-基)環(huán)己烷-1-甲酰胺
4-[(1R)-1-氨基乙基]-N-(吡啶-4-基)環(huán)己烷-1-甲酰胺二鹽酸鹽
Y-27632
Y-276322HCl
ROCK INHIBITOR
Y-27632/Y27632
Y-27632 (2HCl),98%
Y-27632, free base
Y-27632 DIHYDROCHLORIDE
Y-27632, Free Base, >99%
4-[(1R)-1-Aminoethyl]-N-(4-pyridinyl)cyclohexanecarboxamide
物理化學(xué)性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/08 | HY-10583 | Y-27632二鹽酸鹽 Y-27632 dihydrochloride | 146986-50-7 | 2 mg | 450元 |
| 2025/02/08 | HY-10583 | Y-27632二鹽酸鹽 Y-27632 dihydrochloride | 146986-50-7 | 5mg | 700元 |
| 2025/02/08 | HY-10583 | Y-27632二鹽酸鹽 Y-27632 dihydrochloride | 146986-50-7 | 10mM * 1mLin DMSO | 770元 |
常見問題列表
|
ROCK-I 220 nM (Ki) |
ROCK-II 300 nM (Ki) |
PKN 3.1 μM (Ki) |
Citron kinase 5.3 μM (Ki) |
PKCα 73 μM (Ki) |
PKA 25 μM (Ki) |
Y-27632 inhibits the ROCK family of kinases 100 times more potently than other kinases including protein kinase C, cAMP-dependent kinase and myosin light chain kinase. Y-27632 prolongs the lag time and delays the appearance of BrdU-labeled cells in a concentration-dependent manner, delays of about 1 and 4 h are noticed in the Swiss 3T3 cells treated with 10 and 100 μM Y-27632, respectively. Y-27632 promotes neuronal differentiation of adipose tissue-derived stem cells (ADSCs). Compared to 1.0 and 2.5 μM Y-27632 induced groups, percentages of neuroal-like cells achieved a peak in the 5.0 μM Y-27632 induced group.
Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of myoclonic jerks when compare with saline group. Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of clonic convulsions when compare with saline group. Treatment with Dimethylnitrosamine (DMN) causes a significant decrease in rat body and liver weight (DMN-S group) compared with control animals (S-S group). Oral Y27632 (30 mg/kg) essentially prevents this DMN-induced rat body and liver weight loss (DMN-Y group).