195611-82-6
195611-82-6 結(jié)構(gòu)式
基本信息
英文別名
GW76042-Propenoic acid, 3-[4-[(1E)-1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenyl]-, (2E)-
常見(jiàn)問(wèn)題列表
生物活性
GW7604 是一種抗雌激素藥。GW7604 是 GW5638 的代謝物。GW5638 是一種高親和力的雌激素受體 (ER) 拮抗劑。體外研究
GW7604 is the presumed metabolite of GW5638 in breast (MCF-7) and endometrial (ECC-1) cell lines. GW7604 (0.1 nM-1 μM; 24 hours) inhibits both Estradiol (1 nM) and 4-hydroxytamoxifen (4-OHT; 10 and 100 nM) induction of TGF-alpha in a concentration related manner (1-1000 nM) in MDA-MB-231 cells.
Western Blot Analysis
| Cell Line: | MDA-MB-231 cells |
| Concentration: | 0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM |
| Incubation Time: | 24 hours |
| Result: | Blocked the effect of estradiol (E2; 1 n M) in a concentration-related manner. |