192322-50-2
中文名稱
192322-50-2
英文名稱
CGP 71683 HYDROCHLORIDE
CAS
192322-50-2
分子式
C26H30ClN5O2S
分子量
512.07
MOL 文件
192322-50-2.mol
更新日期
2024/06/12 17:31:29
192322-50-2 結(jié)構(gòu)式
基本信息
中文別名
鹽酸CGP71683N-[[反式-4-[[(4-氨基-2-喹唑啉基)氨基]甲基]環(huán)己基]甲基]-1-萘磺酰胺鹽酸鹽
N-(((1R,4R)-4-(((4-氨基喹唑啉-2-基)氨基)甲基)環(huán)己基)甲基)萘-1-磺酰胺鹽酸鹽
英文別名
CGP 71683CGP71683HCl
UNII-45B73P82A3
CGP 71683 HYDROCHLORIDE
CGP 71683A hydrochloride
CGP-71683A
CGP 71683A
CGP71683A
UNII-45B73P82A3
N-[[TRANS-4-[[(4-AMINO-2-QUINAZOLINYL)AMINO]METHYL]CYCLOHEXYL]METHYL]-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE
1-Naphthalenesulfonamide, N-[[trans-4-[[(4-amino-2-quinazolinyl)amino]methyl]cyclohexyl]methyl]-, hydrochloride (1:1)
物理化學(xué)性質(zhì)
儲(chǔ)存條件Inert atmosphere,2-8°C
溶解度H2O: ~14 mg/mL, soluble
溶解度H2O：14 mg/mL，可溶
形態(tài)solid
顏色off-white
常見問題列表
生物活性
CGP71683 hydrochloride (CGP71683A) 是一種競(jìng)爭(zhēng)性的、選擇性 neuropeptide Y receptor type 5 (Y5 receptor) 拮抗劑，其Ki值為1.3 nM。靶點(diǎn)
| Target | Value |
|
Y5 receptor
(Cell-free assay) | 1.3 nM(Ki) |
體外研究
CGP71683 hydrochloride is a competitive neuropeptide Y5 receptor antagonist with a K i of 1.3 nM, and shows no obvious activity at Y1 receptor (K i , >4000 nM) and Y2 receptor (K i , 200 nM) in cell membranes.
體內(nèi)研究
CGP71683 (15 nmol/rat, icv, twice daily) shows anorexigenic effect, reducing food intake and bady weight of fed rats. CGP71683 causes 3-times higher serum total T4 and 37% increase in free T4 in the fasted rats than in the fasted controls rats.