| Identification | Back Directory | [Name]
CGP 71683 HYDROCHLORIDE | [CAS]
192322-50-2 | [Synonyms]
CGP 71683
CGP71683HCl
UNII-45B73P82A3
CGP 71683 HYDROCHLORIDE
CGP 71683A hydrochloride
CGP-71683A; CGP 71683A; CGP71683A; UNII-45B73P82A3
N-[[TRANS-4-[[(4-AMINO-2-QUINAZOLINYL)AMINO]METHYL]CYCLOHEXYL]METHYL]-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE
1-Naphthalenesulfonamide, N-[[trans-4-[[(4-amino-2-quinazolinyl)amino]methyl]cyclohexyl]methyl]-, hydrochloride (1:1) | [Molecular Formula]
C26H30ClN5O2S | [MDL Number]
MFCD07783999 | [MOL File]
192322-50-2.mol | [Molecular Weight]
512.07 |
| Hazard Information | Back Directory | [Description]
CGP 71683 is an antagonist of neuropeptide Y (NPY) receptor Y5 (IC50 = 1.4 nM in a radioligand binding assay). It is selective for Y5 over Y1, Y2, and Y4 receptors (IC50s = 2,765, 7,187, and 5,637 nM, respectively). It inhibits NPY-induced increases in BT-549 cell growth and MDA-MB-231 cell migration when used at a concentration of 0.25 μM. CGP 71683 (10 mg/kg, i.p.) inhibits increases in food intake induced by intracerebroventricular administration of NPY in rats. | [Biological Activity]
Extremely selective, non-peptide NPY Y 5 receptor antagonist. Displays > 1000-fold selectivity over Y 1 , Y 2 and Y 4 receptors; IC 50 values are 1.4, 2765, 7187 and 5637 nM at cloned rat Y 5 , Y 1 , Y 2 and Y 4 receptors respectively. Potently inhibits NPY-induced food intake following i.p. administration in diabetic, free-feeding and fasted rats. | [storage]
Store at +4°C |
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