19186-35-7
19186-35-7 結(jié)構(gòu)式
基本信息
脫氧鬼臼毒素
去氧鬼臼毒素對(duì)照品
去氧鬼臼毒素標(biāo)準(zhǔn)品
脫氧鬼臼毒素,脫氧鬼臼脂素
去氧鬼臼毒素,去氧鬼臼脂素
Nsc403148
Desoxypodophyllotoxin
4-Deoxypodophyllotoxin
(-)-Desoxypodophyllotoxin
Anthricin/Deoxypodophyllotoxin
Podophyllotoxin 9-Desoxy Impurity
Deoxypodophyllotoxin, deoxypodophyllotoxin
Furo[3',4':6,7]naphtho[2,3-D]-1,3-dioxol-6(5ah)-one, 5,8,8A,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-,(5R,5ar,8ar)-
物理化學(xué)性質(zhì)
常見(jiàn)問(wèn)題列表
Deoxypodophyllotoxin (25-75 nM; 6-48 hours) increases the percentage of early apoptotic cell population from 2.05 to 5.62 and 18.49% for 24 h and 48 h, respectively. Deoxypodophyllotoxin (25-75 nM; 6-48 hours) treats SGC-7901 cells arrested in G2/M phase in time- and dose- dependent manners. Deoxypodophyllotoxin (25-75 nM; 6-48 hours) results in a remarkably time- and dose-dependent decrease in Cdc2 and Cdc25C expression levels and increases cyclin B1 within 6h, decreases PARP, Bcl-2 and caspase-3 activity.
Apoptosis Analysis
| Cell Line: | SGC-7901 cells |
| Concentration: | 25, 50, 75 nM |
| Incubation Time: | 6, 12, 24, 48 hours |
| Result: | Induced apoptosis in SGC-7901 Cells. |
Cell Cycle Analysis
| Cell Line: | SGC-7901 cells |
| Concentration: | 25, 50, 75 nM |
| Incubation Time: | 6, 12, 24, 48 hours |
| Result: | Induced G2/M cell cycle arrest in SGC-7901 Cells |
Western Blot Analysis
| Cell Line: | SGC-7901 cells |
| Concentration: | 25, 50, 75 nM |
| Incubation Time: | 6, 12, 24, 48 hours |
| Result: | Altered the expression of cyclin B1, Cdc2,Cdc25C, p-PARP, Bcl-2 and p-caspase-3 proteins. |
Deoxypodophyllotoxin (intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days) suppresses the tumors in a dose-dependent manner, the growth of tumors is inhibited by 22.19%, 47.91% and 50.93% with DPT at 5, 10 and 20 mg/kg, respectively.
| Animal Model: | Xenograft model of gastric cancer in nude mice with SGC-7901 cells |
| Dosage: | 5, 10, and 20 mg/kg |
| Administration: | Intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days |
| Result: | Inhibited the growth of gastric cancer tumors. |