18877-64-0
中文名稱
L-氯化棕櫚酰肉堿
英文名稱
Palmitoyl-L-Carnitine Chloride
CAS
18877-64-0
分子式
C23H46ClNO4
分子量
436.07
MOL 文件
18877-64-0.mol
更新日期
2025/01/16 16:04:28
18877-64-0 結(jié)構(gòu)式
基本信息
中文別名
氯化棕櫚酰L-棕櫚酰基肉堿
L-氯化棕櫚酰肉堿
左旋棕櫚酰肉堿鹽酸鹽
棕櫚酰-L-肉堿鹽酸鹽
棕櫚酰-L-肉堿氯化物
L-肉堿:鹽酸鹽,O-棕櫚酰未標(biāo)記
棕櫚酰-L-肉堿鹽酸鹽
英文別名
Einecs 242-642-6L-CARNITINE:HCL, O-PALMITOYL
L-Palmitoylcarnitine chloride
PALMITOYL-L-CARNITINE CHLORIDE
O-PALMITOYL-L-CARNITINE CHLORIDE
HEXADECANOYL-L-CARNITINE CHLORIDE
Palmitoyl-L-carnitine hydrochloride
Palmitoyl-L-carnitine chloride≥ 99% (TLC)
(R)-3-(Palmitoyloxy)-4-(trimethylammonio)butanoate Hydrochloride
(R)-3-(Hexadecanoyloxy)-4-(trimethylammonio)butyrate Hydrochloride
物理化學(xué)性質(zhì)
熔點(diǎn)168-172 °C(lit.)
儲存條件−20°C
溶解度H2O: 25 mg/mL with heat or sonication
形態(tài)powder
顏色white
BRN4071005
CAS 數(shù)據(jù)庫18877-64-0
安全數(shù)據(jù)
常見問題列表
生物活性
L-Palmitoylcarnitine chloride是一種長鏈?；鈮A和脂肪酸代謝產(chǎn)物，在缺血期間積聚于肌膜并擾亂膜脂環(huán)境。L-Palmitoylcarnitine chloride 通過與 Kir6.2 的相互作用抑制 KATP 通道活性，而不影響單通道電導(dǎo)。靶點(diǎn)
|
Kir6.2
|
Human Endogenous Metabolite
|
體外研究
L-Palmitoylcarnitine (1 μM) inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2. L-Palmitoylcarnitine simultaneously enhances the ATP sensitivity of the channel (IC
50
fell from 62 to 30 μM).
Modulation of the membrane lipid environment caused by L-Palmitoylcarnitine alters the K
ATP
channel function mainly through the interaction with endogenous PI cascade, especially PIP2.