186689-07-6
中文名稱
2-(N-7-硝基-2,1,3-苯并惡二唑-4-氨基)-2-脫氧-D-葡萄糖
英文名稱
2-(N-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)AMINO)-2-DEOXYGLUCOSE
CAS
186689-07-6
分子式
C12H14N4O8
分子量
342.26
MOL 文件
186689-07-6.mol
更新日期
2024/10/23 14:20:58
186689-07-6 結構式
基本信息
中文別名
葡萄糖攝取熒光探針葡萄糖轉運/血糖通道熒光探針2-NBDG
2-(N-7-硝基-2,1,3-苯并噁二唑-4-氨基)-2-脫氧-D-葡萄糖
2-(N-7-硝基-2,1,3-苯并惡二唑-4-氨基)-2-脫氧-D-葡萄糖
2-脫氧-2-[(7-硝基-2,1,3-苯并惡二唑-4-基)氨基]-D-葡萄糖
2-(N-7-硝基-2,1,3-苯并噁二唑-4-氨基)-2-脫氧-D-葡萄糖, 混合物
英文別名
2-NBDGNBD-GLUCOSE
2-NBD-Glucose
2-NBDG min. 95%
2-Deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose
2-(N-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)AMINO)-2-DEOXYGLUCOSE
D-Glucose, 2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-
2-NBDG,2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose
2-Deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose >=97% (HPLC)
2-Deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose, 90%, mixed Isomers
所屬類別
生物化工：生化試劑物理化學性質
熔點137 - 140°C
沸點740.0±70.0 °C(Predicted)
密度1.750±0.06 g/cm3(Predicted)
儲存條件Inert atmosphere,Store in freezer, under -20°C
溶解度溶于DMSO（高達10mg/ml）。
酸度系數(shù)(pKa)12.96±0.20(Predicted)
形態(tài)固體
顏色深黃色至橙色/紅色
BRN7603370
穩(wěn)定性可在-20°下的DMSO中的溶液儲存長達1個月。
常見問題列表
生物活性
2-NBDG，一種熒光脫氧葡萄糖衍生物，是檢測葡萄糖攝取的標志物，也用于檢測細胞活力。體外研究
It has since been demonstrated in living mammalian cells that the uptake of 2-NBDG takes place through glucose transporters (GLUTs) in a concentration-, time- and temperature-dependent manner. A short-period application of 2-NBDG produced a remarkable increase in the fluorescence intensity in COS-1 cells over-expressing GLUT2, whereas the increase was barely detectable in mock-transfected cells. In mouse insulin-secreting clonal MIN6 cells, uptake was inhibited by cytochalasin B, a specific blocker for GLUTs, and by D-glucose in a dose-dependent manner.