1811510-56-1
中文名稱
化合物PF6260933
英文名稱
PF-6260933
CAS
1811510-56-1
分子式
C16H13ClN4
分子量
296.75
MOL 文件
1811510-56-1.mol
更新日期
2023/03/20 15:41:27
1811510-56-1 結(jié)構(gòu)式
基本信息
中文別名
化合物PF6260933 英文別名
PF06260933PF-6260933
[3,3'-Bipyridine]-6,6'-diamine, 5-(4-chlorophenyl)-
PF 06260933
PF06260933
PF6260933
PF 6260933
PF-6260933
所屬類別
生物化工：激動劑抑制劑物理化學(xué)性質(zhì)
沸點483.8±40.0 °C(Predicted)
密度1.330±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: insol; PBS (pH 7.2): insol
酸度系數(shù)(pKa)5.04±0.13(Predicted)
形態(tài)固體
顏色White to off-white
常見問題列表
生物活性
PF-6260933 (PF-06260933)是MAP4K4抑制劑，IC50為3.7 nM，具有良好的激酶組選擇性。靶點
| Target | Value |
|
MAP4K4
() | 3.7 nM |
體外研究
PF-06260933 treatment of human aortic endothelial cell (EC) robustly prevents TNF-α-mediated endothelial permeability in vitro , similar to MAP4K4 knockdown.
體內(nèi)研究
In the mice model, PF-06260933 treatment does not alter plasma lipid content, although reductions in glucose levels are observed, which is consistent with whole-body-inducible Map4k4 knockout animals. PF-06260933 administration ameliorates further plaque development and/or promotes plaque regression in this animal model (46.0% versus 25.5%), and a reduction in plasma glucose as well as lipid content is also observed.