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17817-31-1

中文名稱 4',6,7-三羥異黃酮
英文名稱 6,7,4'-Trihydroxyisoflavone
CAS 17817-31-1
分子式 C15H10O5
MDL 編號(hào) MFCD00016953
分子量 270.24
MOL 文件 17817-31-1.mol
更新日期 2024/11/07 16:37:06
17817-31-1 結(jié)構(gòu)式 17817-31-1 結(jié)構(gòu)式

基本信息

中文別名
4',6',7'-三羥異黃酮
4',6,7-三羥基異黃酮
英文別名
4',6,7-TRIHYDROXYISOFLAVONE
6,7,4'-TRIHYDROXYISOFLAVONE
DEMETHYLTEXASIN
TRIHYDROXYISOFLAVONE, 4',6,7-
TRIHYDROXYISOFLAVONE, 4',6,7-(RG)
6,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
所屬類別
生物化工:提取物

物理化學(xué)性質(zhì)

熔點(diǎn)>280℃
沸點(diǎn)587.1±50.0 °C(Predicted)
密度1.548±0.06 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度溶于二甲基甲酰胺
酸度系數(shù)(pKa)6.85±0.20(Predicted)
形態(tài)粉末晶體
顏色淡黃色至棕色至深綠色
LogP2.170 (est)
CAS 數(shù)據(jù)庫(kù)17817-31-1(CAS DataBase Reference)

常見問題列表

生物活性
Desmethylglycitein (4',6,7-Trihydroxyisoflavone),大豆苷元的代謝產(chǎn)物,來源于大豆 Glycine max,具有抗氧化性和抗癌活性。Desmethylglycitein 在體內(nèi)直接結(jié)合 CDK1 和 CDK2,抑制 CDK1 和 CDK2 活性。Desmethylglycitein 是蛋白激酶 C (PKC)α 的直接抑制劑,抑制正常人皮膚成纖維細(xì)胞中的太陽紫外線 (sUV) 誘導(dǎo)的基質(zhì)金屬蛋白酶1 (MMP1)。Desmethylglycitein 以 ATP 競(jìng)爭(zhēng)方式與細(xì)胞質(zhì)中的 PI3K 結(jié)合,抑制 PI3K 和下游信號(hào)級(jí)聯(lián)的活性,從而抑制 3T3-L1 前脂肪細(xì)胞中的脂肪形成。
靶點(diǎn)

CDK1

CDK2

PKC

體外研究

Desmethylglycitein (4',6,7-Trihydroxyisoflavone)(0-100 μM; 24-72 hours) suppesses anchorage-dependent growth of HCT-116 and DLD1 cells in a dose- and time-dependent manner without cytotoxicity . Desmethylglycitein (4',6,7-Trihydroxyisoflavone)(0-100 μM; 24-72 hours) suppresses CDK1 activity in a dose-dependent manner and inhibits CDK2 activity in HCT-116 cells. Desmethylglycitein (4',6,7-Trihydroxyisoflavone)(0-100 μM; 24-72 hours) induces cell cycle arrest at the S and G2/M phases, the percentage of cells in S phase is higher in the 100 μM 6,7,4′-THIF-treated group, and the same pattern is observed in G2/M phase (29.5% versus 19.1% ) .

Cell Viability Assay

Cell Line: HCT-116 cells
Concentration: 0, 12.5, 25, 50 or 100 μM
Incubation Time: 24, 48 or 72 hours
Result: Inhibited anchorage-dependent and -independent growth of HCT-116 cells.

Western Blot Analysis

Cell Line: HCT-116 and DLD1 cells
Concentration: 0, 25, 50 or 100 μM
Incubation Time: 48 hours
Result: Inhibited CDK1,CDK2 expression.

Cell Cycle Analysis

Cell Line: HCT-116 cells
Concentration: 0, 25, 50 or 100 μM
Incubation Time: 24, 48 or 72 hours
Result: Induces cell cycle arrest of HCT-116 cells at S and G2/M phases.
體內(nèi)研究

Desmethylglycitein (4',6,7-Trihydroxyisoflavone) (intraperitoneally injection; 5 or 25 mg/kg; once daily; 20 days) suppresses tumor development in mice and serves as an effective anticancer treatment with the potential to inhibit or delay the tumorigenicity of HCT-116 cells in an in vivo system.

Animal Model: Female athymic nude mice subcutaneously injected with HCT-116 cells
Dosage: 5 or 25 mg/kg
Administration: Intraperitoneally injection; 5 or 25 mg/kg; once daily; 20 days
Result: Decreased tumor growth, volume and weight of HCT-116 xenografts.
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