171202-16-7
171202-16-7 結(jié)構(gòu)式
基本信息
bpV(phen) (potassium hydrate)
Bisperoxovanadium (Bisperoxovanadium(phen)
物理化學(xué)性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/08 | HY-122818 | bpV(phen) (potassium hydrate) bpV(phen) trihydrate | 171202-16-7 | 5mg | 650元 |
| 2025/02/08 | HY-122818 | bpV(phen) trihydrate | 171202-16-7 | 10 mM * 1 mLin Water | 715元 |
| 2025/02/08 | HY-122818 | bpV(phen) (potassium hydrate) bpV(phen) trihydrate | 171202-16-7 | 10mg | 1050元 |
常見問題列表
IC50: 38 nM (PTEN), 343 nM (PTP-β) and 920 nM (PTP-1B)
Parasite
Leishmania
Apoptosis
bpV(phen) (5 μM; 24.5 hours; H9c2 cells) treatment causes a further decrease of cell viability in H/R-injured H9c2 cells.
bpV(phen) (5 μM; 24.5 hours; H9c2 cells) treatment increases the apoptosis of H/R-injured H9c2 cells.
bpV(phen) (5 μM; 24.5 hours; H9c2 cells) treatment significantly promotes the accumulation of cytoplasmic Cytochrome C in H/R-injured H9c2 cells.
After stimulation of bpV(phen), PTEN-induced putative kinase protein 1 (PINK1)/Parkin-mediated mitophagy is inhibited.
bpV(phen) is an insulin-mimetic agent following insulin-receptor tyrosine kinase hyperphosphorylation and activation.
Cell Viability Assay
| Cell Line: | Hypoxia/reoxygenation (H/R)-injured H9c2 cells |
| Concentration: | 5 μM |
| Incubation Time: | 24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes) |
| Result: | Caused a further decrease of cell viability. |
Apoptosis Analysis
| Cell Line: | Hypoxia/reoxygenation (H/R)-injured H9c2 cells |
| Concentration: | 5 μM |
| Incubation Time: | 24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes) |
| Result: | Increased the apoptosis of H/R-injured H9c2 cells. |
Western Blot Analysis
| Cell Line: | Hypoxia/reoxygenation (H/R)-injured H9c2 cells |
| Concentration: | 5 μM |
| Incubation Time: | 24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes) |
| Result: | Showed an increased release of Cytochrome C. |
bpV(phen) (5 mg/kg; intraperitoneal injection; daily; for 38 days; male BALB/c nude (nu/nu) athymic mice) treatment causes a significant reduction in average tumor volume.
| Animal Model: | Male BALB/c nude (nu/nu) athymic mice (6-7 weeks old) injected with PC-3 cells |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 38 days |
| Result: | Caused a significant reduction in average tumor volume. |