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164579-32-2

中文名稱 泮托拉唑鈉水合物
英文名稱 PantoprazoleSodiumSesquihydrate
CAS 164579-32-2
分子式 C16H15F2N3O4S.3/2H2O.Na
分子量 864.75
MOL 文件 164579-32-2.mol
更新日期 2024/12/22 16:31:02
164579-32-2 結構式 164579-32-2 結構式

基本信息

中文別名
泮托拉唑水合物
泮托拉唑鈉水合物
泮托拉唑鈉水合物1
潘托拉唑鈉1.5水
泮托拉唑鈉1.5水
泮托拉唑鈉倍半水合物
泮托拉唑鈉1.5水合物
泮托拉唑鈉倍半結晶水合物
泮托拉唑鈉水合物 EP標準品
泮托拉唑鈉系統(tǒng)適應 EP標準品
英文別名
Unii-6871619Q5x
BY1023 (sodium hydrate)
SKF-96022 SODIUM HYDRATE
Pantoprazole sodium hydrate
Pantoprazole sodium sesquihydrate CRS
Pantoprazole for system suitability CRS
Pantoprazole Sodium sesqui hydrate- IP/BP/USP
6-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt hydrate (2:2:3)
1H-Benzimidazole, 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-, sodium salt, hydrate (2:3)
Pantoprazole Sodium SesquihydrateQ: What is Pantoprazole Sodium Sesquihydrate Q: What is the CAS Number of Pantoprazole Sodium Sesquihydrate Q: What is the storage condition of Pantoprazole Sodium Sesquihydrate
所屬類別
分析化學:藥典標準品和雜質標準品

物理化學性質

儲存條件4°C, protect from light
溶解度易溶于水和乙醇(96%),幾乎不溶于己烷。
形態(tài)neat
顏色White to off-white

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302
防范說明P301+P312+P330
危險品標志Xn
危險類別碼22
WGK Germanynwg
海關編碼2933399090

常見問題列表

生物活性
Pantoprazole sodium hydrate (BY1023 sodium hydrate) 是一種具有口服活性的,有效質子泵 (proton pump) 抑制劑 (PPI)。Pantoprazole sodium hydrate 是一種取代的苯并咪唑,是一種有效的 H+/K+-ATPase 抑制劑,IC50 為 6.8 μM。Pantoprazo sodium hydrate 可以改善 pH 值穩(wěn)定性,并具有抗分泌,抗?jié)兊淖饔?。Pantoprazo sodium hydrate 聯(lián)合阿霉素 (Doxorubicin; HY-15142) 可顯著增加腫瘤生長延遲。
體外研究

Pantoprazole sodium hydrate (BY1023 sodium hydrate; 1-10000 μM) leads to concentration-dependent increases in endosomal pH in EMT-6 and MCF7 cells.
Pantoprazole sodium hydrate can block exosome release. Pantoprazole sodium hydrate inhibits the activity of V-H + -ATPase and impaires the ability of tumour cells (melanomas, adenocarcinomas, and lymphoma cell lines) to acidify the extracellular medium

體內研究

Pantoprazole sodium hydrate (BY1023 sodium hydrate; 200 mg/kg; IP; once a week for 3 weeks) significantly increases tumor growth delay of MCF-7 xenografts combined with Doxorubicin.
Pantoprazole sodium hydrate (0.3-3 mg/kg, p.o.) dose-dependently decreases both basal acid secretion in pylorus-ligated rats and the stimulated acid secretion induced by mepirizole in acute fistula rats.

Animal Model: Mice bearing MCF-7 or A431 xenografts
Dosage: 200 mg/kg
Administration: IP; once a week for 3 weeks; alone or 2 hours before Doxorubicin (6 mg/kg i.v.)
Result: Showed even greater growth delay of MCF-7 xenografts with Doxorubicin compared with the single-dose combination.
Significantly increased tumor growth delay with a single dose with Doxorubicin.
There is no effect on growth delay alone.
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