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160434-48-0

中文名稱 4-去甲基異氟烷
英文名稱 4-DesMethyl Istradefylline
CAS 160434-48-0
分子式 C19H22N4O4
分子量 370.4
MOL 文件 160434-48-0.mol
更新日期 2024/03/08 11:56:33
160434-48-0 結(jié)構(gòu)式 160434-48-0 結(jié)構(gòu)式

基本信息

中文別名
伊曲茶堿雜質(zhì)14
4-去甲基伊曲茶堿
英文別名
4-DesMethyl Istradefylline
Istradefylline Impurity 14
Istradefylline M1 metabolite
4-DesMethyl Istradefylline impurity
Istradefylline 4-O-Desmethyl Impurity
(E)-1,3-diethyl-8-(4-hydroxy-3-methoxystyryl)-7-methyl-1H-purine-2,6(3H,7H)-dione
1H-Purine-2,6-dione, 1,3-diethyl-3,7-dihydro-8-[2-(4-hydroxy-3-methoxyphenyl)ethenyl]-7-methyl-, (E)- (9CI)

應(yīng)用領(lǐng)域

用途1
4-Desmethyl Istradefylline is an impurity of Istradefylline (I927000), a selective A(2A) antagonist used in the treatment of Parkinson鈥檚 disease. 4-Desmethyl Istradefylline have also been shown to exh ibit inhibitory potency towards adenosine A2A receptors and is classified as its an adenosine A2A receptor antagonist.

常見問題列表

生物活性
4-Desmethyl Istradefylline 是 Istradefylline 的代謝物。Istradefylline 是一種有效的,選擇性的,可口服的 adenosine A2A receptor 拮抗劑,在帕金森疾病模型試驗中,Ki 值為 2.2 nM。
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