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158836-71-6

中文名稱 158836-71-6
英文名稱 nitroflurbiprofen
CAS 158836-71-6
分子式 C19H20FNO5
分子量 361.36
MOL 文件 158836-71-6.mol
158836-71-6 結(jié)構(gòu)式 158836-71-6 結(jié)構(gòu)式

基本信息

中文別名
硝基氟比洛芬
英文別名
HCT 1206
nitroflurbiprofen
Nitroxybutyl flurbiprofen
[1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, 4-(nitrooxy)butyl ester

物理化學性質(zhì)

沸點468.8±45.0 °C(Predicted)
密度1.214±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
形態(tài)Oil
顏色Colorless to light yellow
158836-71-6價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-U00013158836-71-6
Nitroflurbiprofen
158836-71-61mg1600元
2024/11/08HY-U00013158836-71-6
Nitroflurbiprofen
158836-71-65mg3400元
2024/11/08HY-U00013158836-71-6
Nitroflurbiprofen
158836-71-610mg4700元

常見問題列表

生物活性
Nitroflurbiprofen 是一種環(huán)氧合酶 (COX) 抑制劑。
靶點

COX

體內(nèi)研究

In vivo hemodynamic measurements (n = 8/condition) and evaluation of the increased intrahepatic resistance by in situ perfusion (n=5/condition) are performed in rats with thioacetamide-induced cirrhosis that receive either Nitroflurbiprofen (45 mg/kg), Flurbiprofen (30 mg/kg, equimolar concentration to Nitroflurbiprofen), or vehicle by intraperitoneal injection 24 hours and 1 hour prior to the measurements. Treatment with Nitroflurbiprofen, an NO-releasing cyclooxygenase inhibitor, improves portal hypertension without major adverse effects in thioacetamide-induced cirrhotic rats by attenuating intrahepatic vascular resistance, endothelial dysfunction, and hepatic hyperreactivity to vasoconstrictors.

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