158021-47-7
基本信息
(2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇
Α-GALACTOSYL CERAMIDESUPPLIER: FUNAKOSHI CO. LTD.
KRN7000
α-Galactosyl Ceramide Supplier: Funakoshi Co. Ltd.
1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine
(2S,3S,4R)-1-O-(α-D-Galactosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol
N-[(1S,2S,3R)-1-[(α-D-Galactopyranosyloxy)Methyl]-2,3-dihydroxyheptadecyl]hexacosanaMide
α-Galactosyl CeraMide
物理化學(xué)性質(zhì)
常見(jiàn)問(wèn)題列表
NKT cell
Culture supernatants of activated Vα24+NKT-cell cultures stimulated with α-Galactosylceramide pulsed monocyte-derived dendritic cells (Mo-DCs) exhibits antiproliferative activities against melanoma cells. This effect is predominantly due to release of IFN-γ, and to a lesser extent IL-12. Other cytokines, including IL-4 and IL-10, are released but these cytokines have less antiproliferative effects. Vα24+NKT-cells stimulated by α-Galactosylceramide-pulsed Mo-DCs have anti-tumour activities against human melanoma through antiproliferative effects exerted by soluble mediators.
α-Galactosylceramide treatment can protect against spontaneous, carcinogen-, or oncogene-induced primary tumor formation in mice. Consistent with a prime role for IFN-γ in NKT cell-mediated tumor responses, a C-glycoside analog of α-Galactosylceramide that preferentially stimulated IFN-γ production is even more effective than α-Galactosylceramide at preventing metastases of the B16 melanoma.
Since α-Galactosylceramide shows a potent antitumor activity and stimulates the lymphocyte proliferation (LP) on allogeneic mixed lymphocyte reaction (MLR) in the mouse, α-Galactosylceramide is considered to be a nonspecific immunostimulating agent which is a biological response modifier.
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
2024/11/08 | G0509 | α-半乳糖神經(jīng)酰胺 α-Galactosylceramide | 158021-47-7 | 1mg | 1475元 |
2024/11/08 | HY-102022 | (2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇 α-Galactosylceramide | 158021-47-7 | 1mg | 2475元 |
2024/01/25 | HY-102022 | (2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇 α-Galactosylceramide | 158021-47-7 | 5mg | 7500元 |