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158021-47-7

中文名稱 (2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇
英文名稱 KRN7000
CAS 158021-47-7
分子式 C50H99NO9
分子量 858.33
MOL 文件 158021-47-7.mol
更新日期 2024/04/01 16:17:18
158021-47-7 結(jié)構(gòu)式 158021-47-7 結(jié)構(gòu)式

基本信息

中文別名
Α-GALACTOSYL CERAMIDESUPPLIER: FUNAKOSHI CO. LTD.
(2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇
Α-GALACTOSYL CERAMIDESUPPLIER: FUNAKOSHI CO. LTD.
KRN7000
英文別名
KRN7000
α-Galactosyl Ceramide Supplier: Funakoshi Co. Ltd.
1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine
(2S,3S,4R)-1-O-(α-D-Galactosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol
N-[(1S,2S,3R)-1-[(α-D-Galactopyranosyloxy)Methyl]-2,3-dihydroxyheptadecyl]hexacosanaMide
α-Galactosyl CeraMide
Supplier: Funakoshi Co. Ltd.

物理化學(xué)性質(zhì)

熔點(diǎn)125-130°C
沸點(diǎn)939.8±65.0 °C(Predicted)
密度1.04±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C冷凍
溶解度微溶于吡啶(加熱)
酸度系數(shù)(pKa)12.92±0.70(Predicted)
形態(tài)白色固體。
顏色白色至淺米色
穩(wěn)定性吸濕性
CAS 數(shù)據(jù)庫(kù)158021-47-7

安全數(shù)據(jù)

WGK Germany3
海關(guān)編碼2940.00.6000

常見(jiàn)問(wèn)題列表

用途
KRN7000主要用于實(shí)驗(yàn)室有機(jī)合成中和化工醫(yī)藥研發(fā)過(guò)程中,在小鼠的傳染性和自身免疫性疾病中顯示出免疫學(xué)作用。
生物活性
α-Galactosylceramide (α-GalCer) 是一種合成的糖脂,具有抗腫瘤和免疫刺激作用。α-Galactosylceramide 是一種非常有效的 NKT 細(xì)胞激動(dòng)劑,可與 CD1d 有效結(jié)合。α-Galactosylceramide 與 CD1d 的復(fù)合物可與 NKT 細(xì)胞的 T 細(xì)胞抗原受體結(jié)合。
靶點(diǎn)

NKT cell

體外研究

Culture supernatants of activated Vα24+NKT-cell cultures stimulated with α-Galactosylceramide pulsed monocyte-derived dendritic cells (Mo-DCs) exhibits antiproliferative activities against melanoma cells. This effect is predominantly due to release of IFN-γ, and to a lesser extent IL-12. Other cytokines, including IL-4 and IL-10, are released but these cytokines have less antiproliferative effects. Vα24+NKT-cells stimulated by α-Galactosylceramide-pulsed Mo-DCs have anti-tumour activities against human melanoma through antiproliferative effects exerted by soluble mediators.

體內(nèi)研究

α-Galactosylceramide treatment can protect against spontaneous, carcinogen-, or oncogene-induced primary tumor formation in mice. Consistent with a prime role for IFN-γ in NKT cell-mediated tumor responses, a C-glycoside analog of α-Galactosylceramide that preferentially stimulated IFN-γ production is even more effective than α-Galactosylceramide at preventing metastases of the B16 melanoma.
Since α-Galactosylceramide shows a potent antitumor activity and stimulates the lymphocyte proliferation (LP) on allogeneic mixed lymphocyte reaction (MLR) in the mouse, α-Galactosylceramide is considered to be a nonspecific immunostimulating agent which is a biological response modifier.

(2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08G0509α-半乳糖神經(jīng)酰胺
α-Galactosylceramide
158021-47-71mg1475元
2024/11/08HY-102022(2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇
α-Galactosylceramide
158021-47-71mg2475元
2024/01/25HY-102022(2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇
α-Galactosylceramide
158021-47-75mg7500元
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