145317-11-9
中文名稱
BISINDOLYLMALEIMIDE X HYDROCHLORIDE (BIM-X HYDROCHLORIDE)
英文名稱
1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy
CAS
145317-11-9
分子式
C26H22N4O3
分子量
438.478
MOL 文件
145317-11-9.mol
145317-11-9 結(jié)構(gòu)式
基本信息
中文別名
化合物 T10550化合物 T10550,10 MM DMSO 溶液
化合物 BISINDOLYLMALEIMIDE X HYDROCHLORIDE
BISINDOLYLMALEIMIDE X HYDROCHLORIDE (RO 31-8425),PKC抑制劑
3-(8-(氨基甲基)-6,7,8,9-四氫吡啶并[1,2-A]吲哚-10-基)-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮鹽酸鹽
3-(8-(氨基甲基)-6,7,8,9-四氫吡啶并[1,2-A]吲哚-10-基)-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮 X鹽酸鹽
英文別名
BIM XBIM-X hydrochloride
Ro 31-8425 Ro 31-8425
Bisindoylmaleimide X HCl
BIM X
RO 31-8425RO 31-8425
Bisindoylmaleimide X hydrochloride ≥95%
Bisindoylmaleimide X (Ro 31-8425)
BISINDOLYLMALEIMIDE X HYDROCHLORIDE (BIM-X HYDROCHLORIDE)
3-[8-(aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy
物理化學(xué)性質(zhì)
儲(chǔ)存條件Inert atmosphere,2-8°C
溶解度Soluble in DMSO (up to 10 mg/ml)
形態(tài)紅色固體。
顏色Red
生物來源synthetic (organic)
穩(wěn)定性Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
常見問題列表
生物活性
Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) 是一種有效的，選擇性的蛋白激酶 C (PKC) 抑制劑。Bisindolylmaleimide X hydrochloride 也是一種有效的細(xì)胞周期蛋白依賴性激酶 2 (CDK2) 拮抗劑，IC50 為 200 nM。靶點(diǎn)
|
CDK2 200 nM (IC 50 ) |
PKC
|
體外研究
Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride; Ro31-8425 hydrochloride) derivatives acts as an useful tool to compare inhibitor potencies and selectivities for a target of interest.