145317-11-9
中文名稱
BISINDOLYLMALEIMIDE X HYDROCHLORIDE (BIM-X HYDROCHLORIDE)
CAS
145317-11-9
分子式
C26H22N4O3
分子量
438.478
MOL 文件
145317-11-9.mol
145317-11-9 結(jié)構(gòu)式
基本信息
英文別名
BIM XBIM-X hydrochloride
Ro 31-8425 Ro 31-8425
Bisindoylmaleimide X HCl
BIM X
RO 31-8425RO 31-8425
Bisindoylmaleimide X hydrochloride ≥95%
Bisindoylmaleimide X (Ro 31-8425)
BISINDOLYLMALEIMIDE X HYDROCHLORIDE (BIM-X HYDROCHLORIDE)
3-[8-(aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy
常見(jiàn)問(wèn)題列表
生物活性
Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) 是一種有效的，選擇性的蛋白激酶 C (PKC) 抑制劑。Bisindolylmaleimide X hydrochloride 也是一種有效的細(xì)胞周期蛋白依賴性激酶 2 (CDK2) 拮抗劑，IC50 為 200 nM。靶點(diǎn)
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CDK2 200 nM (IC 50 ) |
PKC
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體外研究
Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride; Ro31-8425 hydrochloride) derivatives acts as an useful tool to compare inhibitor potencies and selectivities for a target of interest.