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1428-67-7

中文名稱 2,3-雙(4-羥苯基)丙腈
英文名稱 2,3-BIS(4-HYDROXYPHENYL)-PROPIONITRILE
CAS 1428-67-7
分子式 C15H13NO2
分子量 239.27
MOL 文件 1428-67-7.mol
更新日期 2024/12/23 10:32:13
1428-67-7 結(jié)構(gòu)式 1428-67-7 結(jié)構(gòu)式

基本信息

中文別名
2,3-雙(4-羥苯基)丙腈
英文別名
DPN
SC-4473
Diarylpropionitrile
2,3-bis(p-hydroxyphenyl)propionitrile
2,3-BIS(4-HYDROXYPHENYL)-PROPIONITRILE
propionitrile,2,3-bis(p-hydroxyphenyl)
2,3-Bis(4-hydroxyphenyl)propanenitrile
2,3-Bis(4-hydroxyphenyl)propiononitrile
2,3-Bis(4-hydroxyphenyl)propionitrile >
Benzenepropanenitrile, 4-hydroxy-α-(4-hydroxyphenyl)-

物理化學性質(zhì)

熔點200.0 to 204.0 °C
RTECS號UG0900000
儲存條件-20°C
儲存條件Desiccate at -20°C
溶解度DMSO:可溶10mg/mL,澄清
形態(tài)粉末
顏色白色至米色
水溶解性Soluble in 1eq. NaOH (30 mM), ethanol (100 mM), DMSO (100 mM), DMF (~30 mg/ml), and water (0.5 mg/ml at 25°C).
穩(wěn)定性自購買之日起 1 年內(nèi)保持穩(wěn)定。 DMSO 或乙醇溶液可在 -20°C 下保存長達 1 個月。

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
警示詞警告
危險性描述H319-H400
危險品標志Xi,N
危險類別碼36-50
安全說明26-61
危險品運輸編號UN 3077 9 / PGIII
WGK Germany3
海關(guān)編碼2926.90.4801
危險等級9
2,3-雙(4-羥苯基)丙腈價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08B43852,3-雙(4-羥苯基)丙腈
2,3-Bis(4-hydroxyphenyl)propionitrile
1428-67-710mg480元
2024/11/08B43852,3-雙(4-羥苯基)丙腈
2,3-Bis(4-hydroxyphenyl)propionitrile
1428-67-750mg1795元

常見問題列表

生物活性
DPN (Diarylpropionitrile) 是一種非甾體雌激素受體 ERβ 選擇性配體,其 EC50 值為 0.85 nM。DPN 在許多神經(jīng)系統(tǒng)疾病具有神經(jīng)保護作用。
靶點

ERβ

0.85 nM (EC 50 )

體外研究

DPN has a 70-fold ERα relative binding affinity selectivity, and it is a full ERα agonist with a 78-fold ERα potency selectivity (EC 50 =0.85 nM for ERβ; EC 50 =66 nM for ERα).
DPN (10 nM) prevents morphological alterations from Aβ 1-42 (10 μM)-induced toxicity in cultured cortical neurons.
DPN (0.1-100 nM) decreases ROS levels in a non-dose response manner.
DPN (0.1-100 nM) significantly reduces Aβ 1-42 -stimulated expression of Bax in a non-dose dependent manner.
DPN (0.1-100 nM) reduces activated IL-1 levels induced by Aβ 1-42 treatment on cultured cortical neurons.
DPN (0.1-100 nM) suppresses the Aβ 1-42 -upregulated phosphorylation of JNK and p38.

體內(nèi)研究

DPN (10 μg; s.c.; daily; for 11 days) increases swimming and decreases immobility in the FST, and increases TPH protein expression in the dorsal raphe nucleus (DR) in rat model.

Animal Model: Adult Sprague-Dawley female rats (220-250 g), ovariectomized animal models
Dosage: 10 μg/rat
Administration: Subcutaneous injections, daily, for 11 days
Result: Increased swimming and decreased immobility in the FST.
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