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138736-73-9

中文名稱 HAMNO
英文名稱 HAMNO
CAS 138736-73-9
分子式 C17H13NO2
分子量 263.29
MOL 文件 138736-73-9.mol
更新日期 2025/01/23 16:16:30
138736-73-9 結(jié)構(gòu)式 138736-73-9 結(jié)構(gòu)式

基本信息

中文別名
化合物HAMNO
英文別名
HAMNO
NSC111847
CID 6335338
MLS000737724
NSC111847,HAMNO
HAMNO (NSC111847)
HAMNO >=98% (HPLC)
2(1H)-Naphthalenone, 1-[[(2-hydroxyphenyl)amino]methylene]-
HAMNO
CID 6335338
MLS000737724
NSC111847
NSC-111847
NSC111847

物理化學(xué)性質(zhì)

沸點488.8±45.0 °C(Predicted)
密度1.392±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMF:30.0(Max Conc. mg/mL);113.94(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);113.94(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:30):0.25(Max Conc. mg/mL);0.95(Max Conc. mM)
酸度系數(shù)(pKa)9.98±0.35(Predicted)
形態(tài)結(jié)晶固體
顏色Yellow to orange

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302-H315-H319-H335
HAMNO價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-111285HAMNO
HAMNO
138736-73-95mg500元
2024/11/08HY-111285HAMNO
HAMNO
138736-73-910mM * 1mLin DMSO550元
2024/11/08HY-111285HAMNO
HAMNO
138736-73-910mg800元

常見問題列表

生物活性
HAMNO (NSC-111847) 是一種有效的、選擇性的、具有抗腫瘤活性的 replication protein A (RPA) 的抑制劑。HAMNO 可抑制 ATR 的自磷酸化及ATR誘導(dǎo)的RPA32 Ser33磷酸化。
靶點
TargetValue
RPA
()
ATR
()
體外研究

HAMNO is a novel protein interaction inhibitor of replication protein A (RPA). RPA is involved in the ATR/Chk1 pathway. HAMNO alone inhibits colony formation in both HNSCC cell lines in the low micromolar range. HAMNO combined with etoposide significantly inhibits colony formation to a greater degree than HAMNO alone. After UMSCC38 cells are exposed to HAMNO, increased pan-nuclear γ-H2AX staining occurs in a dose dependent manner. Cancer derived UMSCC38 cells, as well as another cancer cell line, UMSCC11B, have prominent γ-H2AX staining, particularly after incubation with 20 μM HAMNO. Both UMSCC38 and OKF4 cells present increased γ-H2AX staining after addition of HAMNO, with the greatest increase in signal occurring in S-phase.

體內(nèi)研究

In mice, HAMNO slows the progression of UMSCC11B tumors. Ser33 of RPA32, an ATR substrate, is highly phosphorylated after two hours of treatment with 20 μM of etoposide, which is reduced with the addition of 2 μM HAMNO, and is nearly absent at higher concentrations, demonstrating an in vivo effect of HAMNO as an inhibitor of RPA32 phosphorylation by ATR.

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