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138-14-7

中文名稱 去鐵銨
英文名稱 DEFEROXAMINE MESYLATE
CAS 138-14-7
分子式 C26H52N6O11S
分子量 656.79
MOL 文件 138-14-7.mol
更新日期 2024/12/24 08:43:39
138-14-7 結(jié)構(gòu)式 138-14-7 結(jié)構(gòu)式

基本信息

中文別名
去鐵銨
甲磺酸除鐵靈
甲磺酸去鐵敏
甲磺酸去鐵胺
去鐵胺甲磺酸鹽
去鐵胺甲磺酸酯
去鐵銨/去鐵敏
去鐵銨 USP標(biāo)準(zhǔn)品
甲磺酸去鐵胺/去鐵胺
DEFEROX胺甲磺酸鹽
英文別名
DFOM
desferal
Prestwick_988
desferalmesylate
deferoxaminemesilate
deferoxaminebmesylate
DEFEROXAMINE MESYLATE
monomethanesulfonate(sa
Desferioxamine mesylate
desferrioxaminebmesylate
所屬類別
原料藥:解毒藥

物理化學(xué)性質(zhì)

熔點(diǎn)148-149°
儲(chǔ)存條件−20°C
儲(chǔ)存條件2-8°C
溶解度H2O: 50 mg/mL
溶解度H2O:50 mg/mL
形態(tài)powder
顏色white to off-white
水溶解性溶于水至100mM

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H315-H319
安全說明22-24/25
安全說明22-24/25
WGK Germany2
WGK Germany2
RTECS號(hào)UG5310000
海關(guān)編碼29280000
毒性man,TDLo,parenteral,16gm/kg/34W-I (16000mg/kg),CARDIAC: PERICARDITISGASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINEBLOOD: OTHER CHANGES,American Journal of Kidney Diseases. Vol. 10, Pg. 71, 1987.
去鐵銨價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/0846177甲磺酸去鐵胺
Deferoxamine mesylate, 95%
138-14-71g3817元
2024/11/08S5742去鐵銨
Deferoxamine mesylate
138-14-725mg1041.12元
2024/11/08S5742去鐵銨
Deferoxamine mesylate
138-14-710mM(1mL in DMSO)1122.65元

常見問題列表

生物活性
Deferoxamine mesylate (Desferrioxamine B, DFOM)是Deferoxamine的甲磺酸鹽,它可形成鐵絡(luò)合物并用作螯合劑。Deferoxamine 是一種鐵死亡的抑制劑,可在體外低氧和高血糖狀態(tài)下穩(wěn)定 HIF-1α 的表達(dá)并改善HIF-1α的活性。Deferoxamine 可降低 beta-amyloid (Aβ) 的沉積并誘導(dǎo)自噬。
靶點(diǎn)
TargetValue
HIF-1α
()
Beta Amyloid
()
Ferroptosis
()
體外研究

Deferoxamine treatment significantly increases HIF-1α binding under all culture conditions, including hypoxic and high-glucose. The mechanism of deferoxamine is through improving HIF-1α biological function through scavenging oxygen free radicals. Deferoxamine (5 μM) has significant effect on the tumor-associated stromal cells cellular multiplication, and cells die at day 7 after exposure to 50 μM and 100 μM deferoxamine. Deferoxamine (5 μM-100 μM) inhibits the proliferation of BMMSCs, and induces apoptosis of MSCs in a dose-dependent manner. Deferoxamine influences the expression of adhesion proteins on MSCs. Deferoxamine (30, 60, 120?μM) shows lower expression of HIF-1α in a concentration dependent way in AdMSCs.

體內(nèi)研究

Deferoxamine (100 mg/kg, i.p.) lowers the mortality rate of subarachnoid hemorrhage (SAH) rat. Deferoxamine (100 mg/kg, i.p.) attenuates Evan’s blue extravasation in cortex, ameliorates the tight junction detachment and preserves the integrity of the base membrane examined in electron microscope at day 3 after SAH. Deferoxamine attenuates degradation of BBB proteins after SAH and significantly reduces ferritin expression at day 3 in the cortex, and improves neurologic behavior and cognitive deficits after experimental. Ten μL of 1 mM deferoxamine-treated wounds display significantly accelerated healing from day 7 onward and heal significantly faster than control-treated wounds in diabetic mice. Deferoxamine-treated wounds and dimethyloxalylglycine-treated wounds heal significantly faster than control-treated wounds in aged mice. In deferoxamine (10 mg/mL)-treated TG mice, there is a decrease in both soluble and insoluble Aβ40 and Aβ42. Both pGSK3β and β-catenin are significantly increased by approximately 50% in the deferoxamine-treated mice.

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