136831-49-7
中文名稱
TYRPHOSTIN RG 14620
英文名稱
TYRPHOSTIN RG 14620
CAS
136831-49-7
分子式
C14H8Cl2N2
分子量
275.13
MOL 文件
136831-49-7.mol
更新日期
2024/11/11 16:20:33
136831-49-7 結(jié)構(gòu)式
基本信息
中文別名
化合物RG 14620EGFR抑制劑(RG14620)
酪氨酸磷酸化抑制劑RG14620
酪氨酸磷酸化抑制劑RG14620
TYRPHOSTIN RG 14620 酪氨酸磷酸化抑制劑RG14620
英文別名
RG-14620RG14620, >98%
Tyrphostin RG
TYRPHOSTIN RG 14620
RG 14620,, 136831-49-7
TYRPHOSTIN RG14620, >98%
RG 14620
RG-14620
TYRPHOSTIN RG14620
2-(3-Pyridinyl)-3-(3,5-dichlorophenyl)propenenitrile
3-(3,5-Dichlorophenyl)-2-(pyridin-3-yl)acrylonitrile
2-(3',5'-DICHLOROPHENYL)-1-(3''-PYRIDINYL)ACRYLONITRILE
物理化學(xué)性質(zhì)
熔點(diǎn)150-151℃
沸點(diǎn)418.2±45.0 °C(Predicted)
密度1.355±0.06 g/cm3(Predicted)
儲(chǔ)存條件−20°C
溶解度DMSO: soluble
酸度系數(shù)(pKa)2.97±0.12(Predicted)
形態(tài)固體
顏色白色至淺黃色
敏感性感光
常見問(wèn)題列表
生物活性
RG14620 (Tyrphostin RG14620)是一種EGFR抑制劑，可直接抑制ABCG2/BCRP的傳送功能。靶點(diǎn)
| Target | Value |
|
EGFR
() | |
|
ABCG2
() |
體外研究
RG14620 inhibits colony formation (IC 50 =3 μM) and DNA synthesis (IC 50 =1 μM) by HER 14 cells, which are stimulated by 50 ng/mL EGF, in a dose-dependent manner. RG14620 also suppresses colony formation(IC 50 =4 μM) and DNA synthesis (IC 50 =1.25 μM) by EGF-stimulated MH-85 cells in a dose-dependent manner. The growth-inhibitory effect of RG14620 irreversible.
體內(nèi)研究
RG14620, at a dose of 200 g/mouse/day inhibits H-85 tumor growth in nude mice. Mice show less cachexia and hypercalcemia, eat more food, and are more active than untreated MH-85 tumor-bearing animals.