1358575-02-6
中文名稱
化合物FTBMT
英文名稱
FTBMT
CAS
1358575-02-6
分子式
C19H16F4N4O
分子量
392.35
MOL 文件
1358575-02-6.mol
更新日期
2024/06/12 17:31:29
1358575-02-6 結(jié)構(gòu)式
基本信息
中文別名
化合物FTBMT 英文別名
FTBMTFTBMT >=98% (HPLC)
inhibit,FTBMT,Inhibitor
4-(3-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-5 -methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide
Benzamide, 4-[3-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1H-1,2,4-triazol-1-yl]-2-methyl-
物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO:69.62(Max Conc. mg/mL);177.44(Max Conc. mM)
形態(tài)Solid
顏色Light yellow to orange
化合物FTBMT價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-101787 | 化合物FTBMT FTBMT | 1358575-02-6 | 5mg | 1100元 |
| 2024/11/08 | HY-101787 | 化合物FTBMT FTBMT | 1358575-02-6 | 10 mM * 1 mLin DMSO | 1210元 |
| 2024/11/08 | HY-101787 | 化合物FTBMT FTBMT | 1358575-02-6 | 10mg | 1800元 |
常見(jiàn)問(wèn)題列表
生物活性
FTBMT 是選擇性的 GPR52 激動(dòng)劑， EC50 為 75 nM。FTBMT 有抗精神病和促進(jìn)認(rèn)知活性。靶點(diǎn)
IC50: 75 nM (GPR52)
體外研究
FTBMT (0.1-10 μM) increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC 50 s of 7.03, 6.85, and 6.87, respectively.
Cell Viability Assay
| Cell Line: | CHO cells (expressing GPR52 receptors) cAMP assay |
| Concentration: | 0.1-10 μM |
| Incubation Time: | 30 minutes |
| Result: | FTBMT activated cAMP signaling in vitro [1] . |
體內(nèi)研究
FTBMT (30 mg/kg, 90 minutes) exhibits antipsychotic-like activity without causing catalepsy in mice.
FTBMT (3 or 10 mg/kg, 48 hours) improves recognition and spatial working memory in rats.
FTBMT (3, 10, 30 mg/kg, 2 hours) stimulates neuronal activity in brain regions related to cognition.
| Animal Model: | Male Long-Evans rats (9 weeks old) |
| Dosage: | 10 mg/kg |
| Administration: | Oral, 1 hour before memory test |
| Result: | A 1-hour pretreatment with FTBMT (10 mg/kg, p.o.) significantly decreases the number of memory errors induced by MK-801 [2] . |
| Animal Model: | Male ICR mice (7 to 8 weeks old) |
| Dosage: | 3–30 mg/kg |
| Administration: | Oral, 60 minutes before s.c. administration of MK-801 |
| Result: | FTBMT increases phospho-DARPP32 levels in the NAc slices [2] . |