| Identification | Back Directory | [Name]
FTBMT | [CAS]
1358575-02-6 | [Synonyms]
FTBMT
FTBMT >=98% (HPLC)
Benzamide, 4-[3-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1H-1,2,4-triazol-1-yl]-2-methyl- | [Molecular Formula]
C19H16F4N4O | [MDL Number]
MFCD31693831 | [MOL File]
1358575-02-6.mol | [Molecular Weight]
392.35 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:69.62(Max Conc. mg/mL);177.44(Max Conc. mM) | [form ]
Solid | [color ]
Light yellow to orange |
| Hazard Information | Back Directory | [Uses]
FTBMT is a GPR52 receptor agonist with an EC50 value of 71 nM. Studies demonstrate antipsychotic-like effects of FTBMT in murine models of schizophrenia. FTBMT elicits beneficial effects on cognitive processes such as spatial working memory and long-term memory in mice. | [Biological Activity]
FTBMT is an orally availableselective and potent agonist of GPR52. It exhibits antipsychotic and procognitive properties without causing catalepsy in rodents. FTBMT improves recognition memory in a novel object recognition test and mitigates MK-801-induced working memory deficits in a radial arm maze test in rats. | [in vivo]
TP-024 (FTBMT) (30 mg/kg, 90 minutes) exhibits antipsychotic-like activity without causing catalepsy in mice[2].
TP-024 (3 or 10 mg/kg, 48 hours) improves recognition and spatial working memory in rats[2]. TP-024 (3, 10, 30 mg/kg, 2 hours) stimulates neuronal activity in brain regions related to cognition[2]. | Animal Model: | Male Long-Evans rats (9 weeks old)[2] | | Dosage: | 10 mg/kg | | Administration: | Oral, 1 hour before memory test | | Result: | A 1-hour pretreatment with FTBMT (10 mg/kg, p.o.) significantly decreases the number of memory errors induced by MK-801[2]. |
| Animal Model: | Male ICR mice (7 to 8 weeks old)[2] | | Dosage: | 3–30 mg/kg | | Administration: | Oral, 60 minutes before s.c. administration of MK-801 | | Result: | FTBMT increases phospho-DARPP32 levels in the NAc slices[2]. |
| [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
http://m.is0513.com/ShowSupplierProductsList927327/0.htm |
|