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133448-20-1

中文名稱 腦利鈉肽
英文名稱 BNP-32 (RAT)
CAS 133448-20-1
分子式 C146H239N47O44S3
分子量 3452.94
MOL 文件 133448-20-1.mol
更新日期 2024/12/16 11:45:47
133448-20-1 結(jié)構(gòu)式 133448-20-1 結(jié)構(gòu)式

基本信息

中文別名
腦利鈉肽
B型利鈉肽
BNP-32 (鼠)
小鼠腦鈉尿肽(1-32)
BNP-32 (鼠), ≥97% (HPLC)
英文別名
BNP RAT
BNP-32 (RAT)
BNP (1-32) RAT
BNP (51-95), RAT
BNP-32 (rat) trifluoroacetate
NSKMAHSSSCFGQKIDRIGAVSRLGCDGLRLF
BRAIN NATRIURETIC PEPTIDE-32 (RAT)
Rat brain natriuretic peptide(1-32)
BRAIN NATRIURETIC PEPTIDE (1-32), RAT
14-45-Brain natriuretic peptide-45 (rat)
所屬類別
生物:小分子化合物

物理化學(xué)性質(zhì)

密度1.50±0.1 g/cm3(Predicted)
儲存條件-20°C
形態(tài)powder
水溶解性溶于水

安全數(shù)據(jù)

WGK Germany3
腦利鈉肽價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2023/03/20HY-P1519腦利鈉肽
Brain Natriuretic Peptide (1-32), rat
133448-20-1500μg2600元
2023/03/20HY-P1519腦利鈉肽
Brain Natriuretic Peptide (1-32), rat
133448-20-11mg3900元
2023/03/20HY-P1519腦利鈉肽
Brain Natriuretic Peptide (1-32), rat
133448-20-15mg11000元

常見問題列表

生物活性
Brain Natriuretic Peptide (1-32), rat (BNP (1-32), rat) 是一種含有 32 個氨基酸的多肽。可作為心力衰竭病人病殘率和死亡率的生化標(biāo)志。
體外研究

B-type natriuretic peptide (BNP) combats cardiac stress by reducing blood pressure and ventricular fibrosis. Rat BNP BNP (1-32) (rBNP (1-32)) is an amino-truncated form of the 45 residue natural rat form of BNP. Atrial natriuretic peptide-(1-28) (ANP), brain natriuretic peptide-(1-32) (BNP) and C-Type natriuretic polypeptide (CNP) occur in the brain, are concentrated in the anteroventral area of the third cerebral ventricle and participate in the regulation of body fluid homeostasis. The ANP(1-28), BNP (1-32) and CNP(1-32) function in the mammalian brain to regulate salt and water homeostasis via their receptors NPR-A and NPR-B.

體內(nèi)研究

The depressor, natriuretic and cyclic GMP responses to several species of brain natriuretic peptide (BNP) are compared to atrial natriureticpeptide (ANP) 99-126 in conscious spontaneously hypertensive rats (SHR) and in conscious cynomolgus monkeys treated with vehicle or the selective neutral endopeptidase inhibitor SQ 28603. In the conscious SHR, the natriuretic and cyclic GMP responses to 3 nmol/kg i.v. rat BNP (1-32) greater than rat ANP 99-126 greater than pig BNP-26 and sre significantly potentiated by 100 mumol/kg i.v. SQ 28,603. Human BNP-32 is inactive in the SHR treated with either vehicle or SQ 28,603. In contrast, 1 nmol/kg i.v. of human BNP (1-32) stimulates renal and depressor responses in the conscious monkeys that are greater than or equal to those elicited by human ANP 99-126, whereas 3 nmol/kg i.v. rat BNP (1-32) reduces mean arterial pressure without affecting renal function.

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