129580-63-8
中文名稱
順式-二氯-反式-二乙酸-氨-環(huán)己胺合鉑
英文名稱
Satraplatin
CAS
129580-63-8
分子式
C10H22Cl2N2O4Pt
分子量
500.28
MOL 文件
129580-63-8.mol
更新日期
2024/11/04 08:50:32
129580-63-8 結(jié)構(gòu)式
基本信息
中文別名
賽特鉑塞特鉑
順式-二氯-反式-二乙酸-氨-環(huán)己胺合鉑
順式-二氯-反式-二乙酸-順式-氨,環(huán)己胺合鉑(IV)
英文別名
JM 216C081294
BMY 45594
BMS 182751
SATRAPLATIN
Satraplatin(JM216)
BMS-182751
BMY-45594
JM-216
bis(acetato-o)amminedichloro(cyclohexanamine)-pt
Bis-acetatoamminedichlorocyclohexylamine platinum(iv)
(OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum
物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF: 0.16 mg/mL; DMSO: 0.5 mg/mL
形態(tài)粉末
顏色Off-white to yellow
常見(jiàn)問(wèn)題列表
生物活性
Satraplatin 是一種烷化劑 (alkylator)，具有抗腫瘤效果。體外研究
Satraplatin needs to avoid light in the solution, and it is unstable in the alkaline state but stable in the acidic state.Satraplatin has potent antitumor activity. Satraplatin combined with dichloroacetate (DCA) inhibits UMC-11 cells with an IC 50 of 1.36 ± 0.11 μM. Satraplatin also suppresses CDDP-resistant (KB-R) cells (IC 50 , 7.04 μM), and causes G2/M arrest in KB-R cells.