120638-55-3
120638-55-3 結(jié)構(gòu)式
基本信息
溴酚酸鈉
溴芬那酸鈉
溴芬酸鈉水合物
溴芬那酸鈉水合物
溴芬酸鈉120638-55-3
(2-氨基-3-(4-溴苯甲酰)苯基)乙酸鈉
(2-氨基-3-(4-溴苯甲酰)苯基)乙酸鈉水合物
(2-氨基-3-(4-溴苯甲酰)苯基)乙酸鈉倍半水合物
Unii-8ecv571Y37
Bromfenac sodiu
Bromfenac ophthalmic
acetate hydrate(2:2:3)
Bromfenac sodium hydrate
BroMfenac sodiuM 1.5H2O
Sodium bromfenate hydrate
Bromfenac ophthalmic solution
Bromfenac Sodium Sesquihydrate
物理化學(xué)性質(zhì)
常見(jiàn)問(wèn)題列表
|
COX-1 5.56 nM (IC 50 ) |
COX-2 7.45 nM (IC 50 ) |
Bromfenac (90 μg/mL; 48 h) inhibits TGF-b1-induced extracellular matrix (ECM) synthesis and myo?broblast activation in HConFs and HPFs.
Bromfenac (30-90 μg/mL; 48 h) decreases the protein and mRNA expression levels of FN, COL3, a-SMA, and survivin in a dose-dependent manner in HConFs and HPFs.
Bromfenac (30-90 μg/mL; 48 h) declines the phosphorylated protein levels of AKT, ERK1/2, and GSK-3b-S9 with dosage in HPFs and HConFs.
Bromfenac (0.0032-3.16%; 100 or 200 μL; rubbed onto the backs) produces significant anti-inflammatory activity at concentrations as low as 0.1% (4 h pretreatment time) or 0.32% (18h pretreatment time) in rats.
Bromfenac (0.032-3.16%; 100 μL; rubbed onto the paws) produces dose-related anti-inflammatory activity in rats.
Bromfenac (0.032-1.0%; 50 μL) is 26 times more potent than indomethacin in blocking the erythema when applied directly onto the skin area exposed to UV light in guinea pigs.
Bromfenac (0.0032-0.1%; 50μL; rubbed onto the uninjected paw for 4 h per day and 5 days per week) produces a dose and time dependent reduction in the paw volume of both hind limbs in rats.
Bromfenac (0.32%; 50μL; rubbed onto the abdomen) produces significant blockade of abdominal constriction to ACh challenge in mice.
| Animal Model: | Male Sprague-Dawley rats (150-250 g) are injected carrageenan |
| Dosage: | 0.0032, 0.01, 0.032, 0.1, 0.32, 1.0, 3.16% (100 or 200 μL) |
| Administration: | Rubbed onto the backs before 1-72 h of injected carrageenan |
| Result: |
Produced significant anti-inflammatory activity when applied 1, 2, and 4 h prior to carrageenan challenge at 0.32%.
Applied 1 or 4 h prior to carrageenan challenge was active, but not when applied 24 h (or longer) prior to challenge at 0.2%. |