112137-89-0
112137-89-0 結(jié)構(gòu)式
基本信息
中文別名
米索前列醇酸米索前列醇酸[干冰運輸]
米索前列醇酸,外消旋混合物
(11ALPHA,13E)-11,16-二羥基-16-甲基-9-氧代-前列腺-13-烯-1-酸
英文別名
MISOPROSTOL ACIDMISOPROSTOL FREE ACID
Misoprostol Acid USP/EP/BP
Misoprostol acid,racemic mixture
Misoprostol Acid, Technical Grade 65%
Misoprostol Acid (10 mg in 1 mL Methyl Acetate)
(-15-Deoxy-(16RS)-16-hydroxy-16-methylprogestaglandin E
(+/-)-15-DEOXY-[16RS]-16-HYDROXY-16-METHYLPROSTAGLANDIN E1
(+/-)-15-Deoxy-(16RS)-16-hydroxy-16-methylprogestaglandin E1
(11a,13E)-11,16-Dihydroxy-16-methyl-9-oxo-prost-13-en-1-oic Acid
所屬類別
原料藥：前列腺素類藥物理化學(xué)性質(zhì)
沸點538.3±50.0 °C(Predicted)
密度1.118±0.06 g/cm3(Predicted)
儲存條件-20°C
溶解度Chloroform
酸度系數(shù)(pKa)4.77±0.10(Predicted)
形態(tài)黃色粘稠油狀物。
顏色淡黃色
穩(wěn)定性對溫度敏感
常見問題列表
生物活性
Misoprostol acid 是一種 Misoprostol 的活性代謝物。Misoprostol 是前列腺素 E1 (PGE1) 的合成類似物，被廣泛吸收，口服后迅速在胃腸道中轉(zhuǎn)化成 Misoprostol acid。Misoprostol 可用于非甾體類抗炎藥誘發(fā)的 (NSAID) 胃潰瘍，還可用于引產(chǎn)的研究。靶點
Prostaglandin E1 (PGE1)
體內(nèi)研究
Unlike the Misoprostol, Misoprostol acid is detectable in plasma. Misoprostol is a lipophilic methyl ester prodrug and is readily metabolized to the free acid, which is the biologically active form. Misoprostol is used worldwide for a variety of indications in obstetrics and gynecology. Misoprostol has both gastric antisecretory and mucosal protective effects.