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105118-14-7

中文名稱 105118-14-7
英文名稱 Datelliptium
CAS 105118-14-7
MOL 文件 105118-14-7.mol
更新日期 2023/02/22 11:54:00
105118-14-7 結(jié)構(gòu)式 105118-14-7 結(jié)構(gòu)式

基本信息

中文別名
化合物DATELLIPTIUM CHLORIDE
DATELLIPTIUM CHLORIDE鹽酸鹽
2-[2-(二乙氨基)乙基]-9-羥基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑,氯化物(1:1)
英文別名
Datelliptium
所屬類別
生物化工:抑制劑

物理化學(xué)性質(zhì)

儲存條件-20°C儲存
溶解度DMSO:5.0(Max Conc. mg/mL);12.56(Max Conc. mM)
H2O:41.67(Max Conc. mg/mL);104.71(Max Conc. mM)
形態(tài)Solid
顏色Pink to red
2-[2-(二乙氨基)乙基]-9-羥基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2023/01/06S0180105118-14-7
Datelliptium chloride
105118-14-75mg20320.5元

常見問題列表

生物活性
Datelliptium chloride 是一種源于 ellipticine 的 DNA 嵌合劑,具有抗腫瘤活性。
體外研究

Datelliptium (100 μM) shows significantly cytotoxic effects after 2 hr of treatment in suspension and primary cultures of rat hepatocytes. Datelliptium mobilizes glycogen in both rat systems in vitro concentration dependently. The half-maximal effect is 14.3 μM in isolated hepatocytes, whereas in cultured rat hepatocytes it is 5.9 μM. Datelliptium also leads to a concentration-dependent decrease in gluconeogenesis from lactate in cells. Datelliptium acetate is selectively cytotoxic for solid tumors over leukemia L1210. Human tumors H-125 and HCT-116 demonstrates less sensitivity to datelliptium acetate.

體內(nèi)研究

Upon intravenous administration, datelliptium acetate shows potent inhibitory activities in vivo against a variety of murine solid tumors. Datelliptium acetate is highly active against early-stage colon #38 with highest non-toxic dose (HNTD) of 170 mg/kg TD, and weight loss of 10%, T/C of 0%.

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