| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:5.0(Max Conc. mg/mL);12.56(Max Conc. mM)
H2O:41.67(Max Conc. mg/mL);104.71(Max Conc. mM) | [form ]
Solid | [color ]
Pink to red |
| Hazard Information | Back Directory | [Uses]
Datelliptium chloride is a DNA-intercalating agent derived from ellipticine, with anti-tumor activities. | [in vivo]
Upon intravenous administration, datelliptium acetate shows potent inhibitory activities in vivo against a variety of murine solid tumors. Datelliptium acetate is highly active against early-stage colon #38 with highest non-toxic dose (HNTD) of 170 mg/kg TD, and weight loss of 10%, T/C of 0%[2]. | [storage]
Store at -20°C | [References]
[1] Donato MT, et al. Toxicity of the antitumoral drug datelliptium in hepatic cells: Use of models in vitro for the prediction of toxicity in vivo. Toxicol In Vitro. 1992 Jul;6(4):295-302. DOI:10.1016/0887-2333(92)90019-n
[2] Mucci-LoRusso P, et al. Activity of datelliptium acetate (NSC 311152; SR 95156A) against solid tumors of mice. Invest New Drugs. 1990 Aug;8(3):253-61. DOI:10.1007/BF00171834 |
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DC Chemicals
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