104012-37-5
104012-37-5 結(jié)構(gòu)式
基本信息
款冬酮(款冬素
款冬素,款冬花素
款冬酮(分析標(biāo)準(zhǔn)品)
款冬酮, 來源于款冬花
款冬素,款冬花素,款冬花酮
款冬酮(款冬素,款冬花素,款冬花酮
Tussilagone
Tussilagone, 98%, from Farfarae Flos
(1R,3aR,5R,7S,7aS)-1-(1-acetyloxyethyl)-4-methylidene-2-oxo-7-propan-2-yl-3,3a,5,6,7,7a-hexahydro-1H-inden-5-yl](E)-3-methylpent-2-enoate
2-Pentenoic acid, 3-methyl-, (1S,3aR,5R,7S,7aS)-1-[(1R)-1-(acetyloxy)ethyl]octahydro-4-methylene-7-(1-methylethyl)-2-oxo-1H-inden-5-yl ester, (2E)-
物理化學(xué)性質(zhì)
應(yīng)用領(lǐng)域
藥理藥效:有升壓、呼吸興奮作用
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/08 | HY-N1388 | 款冬酮 Tussilagone | 104012-37-5 | 1 mg | 480元 |
| 2025/02/08 | HY-N1388 | 款冬酮 Tussilagone | 104012-37-5 | 10 mM * 1 mLin DMSO | 1027元 |
| 2025/02/08 | HY-N1388 | 款冬酮 Tussilagone | 104012-37-5 | 5mg | 1195元 |
常見問題列表
Tussilagone suppressed the expression of the inflammatory mediators, nitric oxide and prostaglandin E2, and the inflammatory cytokines, tumor necrosis factor-alpha (TNF-α) and high-mobility group box 1 (HMGB1), in lipopolysaccharide-stimulated RAW 264.7 cells and peritoneal macrophages. Tussilagone also reduced the activation of the mitogen-activated protein kinases and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) involved in the activation of various inflammatory mediators in activated macrophages.
Tussilagone administration (1 mg/kg and 10 mg/kg) produced decreased mortality and lung injury in CLP-activated septic mice. Augmented expression of cyclooxygenase (COX)-2 and TNF-α in pulmonary alveolar macrophages of septic mice were attenuated by tussilagone administration.