1035979-44-2
中文名稱
(4S,4AS,5AR,12AS)-4-(二甲基氨基)-1,4,4A,5,5A,6,11,12A-八氫-3,10,12,12A-四羥基-7-[(甲氧基甲基氨基)甲基]-1,11-二氧代-2-并四苯甲酰胺鹽酸鹽
英文名稱
P005672 hydrochloride
CAS
1035979-44-2
分子式
C24H30ClN3O8
分子量
523.963
MOL 文件
1035979-44-2.mol
更新日期
2024/12/26 17:36:50
1035979-44-2 結(jié)構(gòu)式
基本信息
中文別名
沙雷霉素鹽酸沙林霉素
米諾環(huán)素雜質(zhì)14
麥芽糖醇雜質(zhì)14
(4S,4AS,5AR,12AS)-4-(二甲基氨基)-1,4,4A,5,5A,6,11,12A-八氫-3,10,12,12A-四羥基-7-[(甲氧基甲基氨基)甲基]-1,11-二氧代-2-并四苯甲酰
(4S,4AS,5AR,12AS)-4-(二甲基氨基)-1,4,4A,5,5A,6,11,12A-八氫-3,10,12,12A-四羥基-7-[(甲氧基甲基氨基)甲基]-1,11-二氧代-2-并四苯甲酰胺鹽酸鹽
英文別名
CS-267P005672
PO05672
P005672 HCl
Sarecycline
PO05672 HCl
Sarecycline HCl
P0-05672
P0 05672
Sarecycline(P005672)
Minocycline Impurity 14
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF: 0.25 mg/ml,DMSO: 0.25 mg/ml
形態(tài)Solid
顏色Light yellow to yellow
常見問題列表
生物活性
Sarecycline hydrochloride 是一種窄譜四環(huán)素類抗生素。Sarecycline hydrochloride 具有抗炎作用和對(duì)革蘭氏陽(yáng)性菌的有效活性，包括對(duì)多種痤瘡角質(zhì)桿菌的活性。Sarecycline hydrochloride 干擾 tRNA 調(diào)節(jié)并將 mRNA 與 70S 核糖體結(jié)合。體外研究
Sarecycline inhibits 55 clinical isolates of
C. acnes
, and the MIC values for Sarecycline ranged from 0.5 to 16?μg/ml; the MIC
50
was 0.5 μg/ml, and the MIC
90
was 4?μg/ml. Sarecycline, exhibits activity against the macrolide-resistant organisms.
Sarecycline hydrochloride exhibits minimal activity against enteric aerobic Gram-negative bacteria.
體內(nèi)研究
Sarecycline hydrochloride (0.33-9?mg/kg; i.v.) show potent activity against S. aureus in a murine neutropenic thigh infection model.
| Animal Model: | Female SD-1 mice (A murine neutropenic thigh wound infection model) |
| Dosage: | 0.33, 1, 3, or 9?mg/kg |
| Administration: | Intravenously |
| Result: | Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32?mg/kg, respectively. |