1033040-23-1
中文名稱
1033040-23-1
英文名稱
TPO agonist 1
CAS
1033040-23-1
分子式
C25H22N8O2
分子量
466.49
MOL 文件
1033040-23-1.mol
1033040-23-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 T17146 英文別名
TPO agonist 11H-Pyrazole-4,5-dione, 1-(3,4-dimethylphenyl)-3-methyl-, 4-[2-[2-hydroxy-3'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]hydrazone]
物理化學(xué)性質(zhì)
沸點(diǎn)703.5±70.0 °C(Predicted)
密度1.42±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)4.25±0.10(Predicted)
形態(tài)Solid
顏色Pink to red
1033040-23-1價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/02/08 | HY-100380 | 1033040-23-1 TPO agonist 1 | 1033040-23-1 | 2mg | 1000元 |
| 2025/02/08 | HY-100380 | 1033040-23-1 TPO agonist 1 | 1033040-23-1 | 5mg | 1400元 |
| 2025/02/08 | HY-100380 | 1033040-23-1 TPO agonist 1 | 1033040-23-1 | 10mM * 1mLin DMSO | 1437元 |
常見(jiàn)問(wèn)題列表
生物活性
TPO agonist 1 是一種 TPO 激動(dòng)劑，可用作血小板生成和巨核細(xì)胞生成的促進(jìn)劑，可用于血小板減少癥的研究。詳細(xì)信息請(qǐng)參考專利文獻(xiàn) WO2008134338A1 中的化合物 TPO mimetic。靶點(diǎn)
TPO receptor
體內(nèi)研究
The thrombopoietin (TPO) receptor agonists are novel treatments for patients with chronic ITP aimed at increasing platelet production through interactions with the TPO receptor on megakaryocytes, and can increases platelet counts, decrease bleeding events and reduce the need for adjunctive or rescue treatments. The TPO receptor agonists are well-tolerated, though uncertainty remains regarding the risk of thromboembolism and bone marrow fibrosis.