| Identification | Back Directory | [Name]
PROGLUMIDE, SODIUM SALT | [CAS]
99247-33-3 | [Synonyms]
PROGLUMIDE SODIUM
PROGLUMIDE, SODIUM SALT
Proglumide sodium salt solid
PROGLUMIDE SODIUM SALT SELECTIVE CHOLECY STOK
4-benzamido-5-(dipropylamino)-5-oxopentanoate
dl-4-benzamido-n,n-dipropylglutaramicacidsodiumsalt
SODIUM;4-BENZAMIDO-5-(DIPROPYLAMINO)-5-OXOPENTANOATE
4-benzamido-n,n-dipropyl-,sodiumsalt,dl-glutaramicaci
4-BENZOYLAMINO-5-DIPROPYLAMINO-5-OXOPENTANOIC ACID SODIUM
Glutaramic acid, 4-benzamido-N,N-dipropyl-, sodium salt, DL-
DL-4-(BENZOYLAMINO)-5-(DIPROPYLAMINO)-5-OXOPENTANOIC ACID, NA
N-Benzoyl-N′,N′-dipropyl-DL-isoglutamine sodium-potassium salt
4-(Benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid sodium salt
pentanoicacid,4-(benzoylamino)-5-(dipropylamino)-5-oxo-,monosodiumsalt,(
4-benzoylamino-5-dipropylamino-5-oxopentanoic acid sodium-potassium salt
N-Benzoyl-Nμ,Nμ-dipropyl-DL-isoglutamine sodium-potassium salt, 4-Benzoylamino-5-dipropylamino-5-oxopentanoic acid sodium-potassium salt | [Molecular Formula]
C18H25N2NaO4 | [MDL Number]
MFCD00069301 | [MOL File]
99247-33-3.mol | [Molecular Weight]
356.39 |
| Hazard Information | Back Directory | [Uses]
Proglumide sodium salt has been used to study the effects of proglumide on macronutrient selection in European sea bass Dicentrarchus labrax, L. | [Biochem/physiol Actions]
Proglumide sodium salt is a non-peptide cholecystokinin receptor antagonist that has greater selectivity for the CCKA subtype. It selectively blocks central nervous system effects. Proglumide sodium salt is orally active. | [in vivo]
Proglumide (250-750 mg/kg; intraperitoneal injection; adult male Sprague Dawley rats) treatment is significantly effective in ameliorating the seizure activities, cognitive dysfunctions, and cerebral oxidative stress[1]. | Animal Model: | Adult male Sprague Dawley rats (200-250?g; 2 months old) are induced status epilepticus (SE)[1] | | Dosage: | 250 mg/kg, 500 mg/kg, and 750?mg/kg | | Administration: | Intraperitoneal injection | | Result: | Dose-dependently and significantly increased the latencies to seizure and SE. Significantly and dose-dependently attenuated Li-PC (SE) induced increase in thiobarbituric acid (TBARS) and catalase (CAT), attenuated Li-Pc induced decrease in SOD, and attenuated depletion of GSH and glutathione-S transferase (GST) in the hippocampus and striatum.
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| [storage]
Desiccate at RT |
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