| Identification | Back Directory | [Name]
2-[2-(2-Propyn-1-yloxy)ethoxy]acetic acid | [CAS]
944561-45-9 | [Synonyms]
Propynyl-PEG1-Ac
Propargyl-PEG1-CH2COOH
2-[2-(2-Propyn-1-yloxy)ethoxy]acetic acid
Acetic acid, 2-[2-(2-propyn-1-yloxy)ethoxy]- | [Molecular Formula]
C7H10O4 | [MDL Number]
MFCD30469070 | [MOL File]
944561-45-9.mol | [Molecular Weight]
158.15 |
| Chemical Properties | Back Directory | [Boiling point ]
294.2±20.0 °C(Predicted) | [density ]
1.169±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
3.37±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
Propynyl-PEG1-Ac is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propynyl-PEG1-Ac is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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