| Identification | Back Directory | [Name]
Propargyl-PEG4-Tos | [CAS]
875770-32-4 | [Synonyms]
Propargyl-PEG4-Tos
Propargyl-PEG5-Tos
3,6,9,12-tetraoxapentadec-14-yn-1-yl 4-methylbenzene-1-sulfonate
3,6,9,12-Tetraoxapentadec-14-yn-1-ol, 1-(4-methylbenzenesulfonate) | [Molecular Formula]
C18H26O7S | [MDL Number]
MFCD28950765 | [MOL File]
875770-32-4.mol | [Molecular Weight]
386.46 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG5-Tos is a PEG linker containing a tosyl group and a propargyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. | [Biological Activity]
Propargyl-PEG4-Tos is a PROTAC linker belonging to the PEG class and can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). | [in vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
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Tags:875770-32-4
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