| Identification | More | [Name]
4-Chloro-1-butanol | [CAS]
928-51-8 | [Synonyms]
4-CHLORO-1-BUTANOL
4-CHLOROBUTANOL
4-CHLOROBUTANOL-1
TETRAMETHYLENE CHLOROHYDRIN
1-Butanol, 4-chloro-
4-Chlorbutan-1-ol
4-Chloro-1-butane-ol
4-chloro-1-butano
4-Chloro-1-hydroxybutane
4-Chlorobutane-1-ol
4-Chlorolbutanol
4-Chloro-n-butylclcohol
Tetramethylenechlorohydrine
4-Chloro-1-butanol, Pract.
4-chlorobutan-1-ol
4-Choro-1-bytanol
4-CHLORO-1-BUTANOL, TECH., CA. 85%
4-Chloro-1-butanol, balance THF andHCl, 85%
4-CHLORO-1-BUTANOL TECH 85%
4-CHLORO-1-BUTANOL GC ABOUT 90% | [EINECS(EC#)]
213-175-5 | [Molecular Formula]
C4H9ClO | [MDL Number]
MFCD00002967 | [Molecular Weight]
108.57 | [MOL File]
928-51-8.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,C,F | [Risk Statements ]
R10:Flammable.
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R34:Causes burns. | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24/25:Avoid contact with skin and eyes .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 2920 8/PG 2
| [WGK Germany ]
3
| [RTECS ]
EL1325000 | [Hazard Note ]
Harmful | [TSCA ]
Yes | [HazardClass ]
3.2 | [PackingGroup ]
III | [HS Code ]
29055910 | [Safety Profile]
Moderately toxic by
ingestion. Questionable carcinogen with
experimental neoplastigenic data. Mutation
data reported. When heated to
decomposition it emits toxic fumes of Cl-.
See also CHLORIDES and ALCOHOLS. |
| Hazard Information | Back Directory | [Chemical Properties]
CLEAR COLOURLESS LIQUID | [Uses]
4-Chloro-1-butanol was employed as an internal standard in the analysis of genotoxic impurities in active pharmaceutical ingredients by GC-MS technique. | [Uses]
4-Chloro-1-butanol is employed as an internal standard in the analysis of genotoxic impurities in active pharmaceutical ingredients by GC-MS technique. | [Uses]
Tetramethylene chlorohydrin is used inorganic synthesis. | [Definition]
ChEBI: A primary alcohol that is butan-1-ol substituted by a chloro group at position 4. | [General Description]
4-Chloro-1-butanol, an alkylating agent, is one of the genotoxic impurity in active pharmaceutical ingredients. Reaction of 4-chloro-1-butanol and Reichardt′s dye has been monitored spectrophotometrically for the determination of genotoxic impurities in pharmaceuticals. | [Health Hazard]
The toxicity of this compound is low. How ever, the acute toxic symptoms are those ofethylene and propylene chlorohydrins. Oralintake of this compound caused muscle con traction, gastrointestinal pain, ulceration, andliver injury in test animals.
LD50 value, oral (mice): 990 mg/kg
Tetramethylene chlorohydrin caused tumorsin lungs in test animals. Its carcinogenicity,however, is not yet fully established. | [Fire Hazard]
Flammable; flash point 36°C (97°F); vapor
density 3.7 (air = 1); the vapor forms an
explosive mixture with air, range is not
reported. Fire-extinguishing agent: “alcohol”
foam; a water spray may be used to cool fire-exposed containers and to flush any spill. It
decomposes to HCl and tetrahydrofuran on
heating. | [Waste Disposal]
Tetramethylene chlorohydrin is burned ina chemical incinerator equipped with anafterburner and scrubber. |
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