| Identification | More | [Name]
Benidipine hydrochloride | [CAS]
91599-74-5 | [Synonyms]
1-(BENZYLMETHYL)-3-PIPERIDINYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOLATE
(R,R)-(+/-)-2,6-DIMETHYL-4-(3-NITROPHENYL)-1,4-DIHYDRO-3,5-PYRIDINE,DICARBOXYLIC ACID METHYL-1-BENZYL-3-PIPERIDYL-ESTER,MONOHYDROCHLORIDE SALT
monohydrochloride,(r*,r*)-(+-)-hyl1-(phenylmethyl)-3-piperidinyleste
2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-DimethoxyCarboxylate
(R,R)-(+/)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacidmethyl-1-(phenylmethyl)-3-piperidiny
Coniel, Capadipine, KW-3049, Nacadipine
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (4R)-rel-
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (R*,R*)-(+-)-
(R,R)-(+/-)-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-Dihydro-3,5-pyridine-dicarboxylic acid methyl-1-benzyl-3-piperidyl-ester hydrochloride
Benidipine hydrochloride
Conipros
rac-(4R*)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R*)-1-benzylpiperidine-3-yl]·hydrochloride | [EINECS(EC#)]
663-500-3 | [Molecular Formula]
C28H31N3O6 | [MDL Number]
MFCD06797587 | [Molecular Weight]
505.56 | [MOL File]
91599-74-5.mol |
| Chemical Properties | Back Directory | [Appearance]
Yellow Crystalline Powder | [Melting point ]
199-201°C | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMSO: ≥20mg/mL | [form ]
powder | [pka]
7.34(at 25℃) | [color ]
yellow | [Usage]
A dihydropyridine calcium channel blocker | [InChIKey]
DGVVISBYHUXFIU-UHFFFAOYSA-N | [CAS DataBase Reference]
91599-74-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
45 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [RTECS ]
US7975657 | [HS Code ]
2933.99.5300 | [Toxicity]
LD50 orally in male mice: 218 mg/kg (Muto, 1988) |
| Hazard Information | Back Directory | [Description]
Benidipine hydrochloride is a new, long acting dihydropyridine calcium antagonist useful in the treatment of hypertension and angina pectoris. In experimental animals,
benidipine hydrochloride dose dependently induced hypotension with a potency of
6 and 12 times more than nifedipine and nicardipine, respectively. It also exhibited a
slow onset of action. | [Chemical Properties]
Yellow Crystalline Powder | [Originator]
Kyowa Hakko (Japan) | [Uses]
A dihydropyridine calcium channel blocker. Antihypertensive. | [Brand name]
Coniel | [Biological Activity]
Orally active antihypertensive agent which displays a wide range of activities in vitro and in vivo . Inhibits L-, N- and T-type Ca 2+ channels. Also inhibits aldosterone-induced mineralocorticoid receptor activation. Exhibits cardioprotective and antiartherosclerotic effects. | [Safety Profile]
A poison by ingestion,intraperitoneal, and intravenous routes. When heated todecomposition it emits toxic vapors of NOx and HCl. | [storage]
room temperature (desiccate) |
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