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ChemicalBook--->CAS DataBase List--->91374-21-9

91374-21-9

91374-21-9 Structure

91374-21-9 Structure
IdentificationMore
[Name]

Ropinirole
[CAS]

91374-21-9
[Synonyms]

4-(2-dipropylaminoethyl)-1,3-dihydroindol-2-one
ROPINIROLE
ROPINIROLE 99%
ROPINIROLE: ROPINIROLE HYDROCHLORIDE
ROPINIROLE INTERMEIDATES:
4-[2-(Dipropylamino)ethyl]-1,3-dihydrcr2H-indol-2-one
SKF-101468
SKF-101468A:ReQuip
4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one
4-[2-(Dipropylamino)ethyl]indoline-2-one
[Molecular Formula]

C16H24N2O
[MDL Number]

MFCD00864147
[Molecular Weight]

260.37
[MOL File]

91374-21-9.mol
Chemical PropertiesBack Directory
[Melting point ]

243-250°C
[Boiling point ]

410.5±45.0 °C(Predicted)
[density ]

1.040±0.06 g/cm3(Predicted)
[pka]

14.17±0.20(Predicted)
[CAS DataBase Reference]

91374-21-9(CAS DataBase Reference)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Indole-->Tetrazole
Safety DataBack Directory
[Hazardous Substances Data]

91374-21-9(Hazardous Substances Data)
Hazard InformationBack Directory
[Uses]

Antiparkinsonian (D2receptor agonist).
[Definition]

ChEBI: Ropinirole is a member of indolones and a tertiary amine. It has a role as a dopamine agonist, an antiparkinson drug, a central nervous system drug and an antidyskinesia agent.
[Brand name]

Requip (GlaxoSmithKline).
[Synthesis Reference(s)]

Journal of Medicinal Chemistry, 28, p. 1533, 1985 DOI: 10.1021/jm00148a028
[Clinical Use]


Anti-Parkinson agent
Restless legs syndrome (RLS)
[Drug interactions]

Potentially hazardous interactions with other drugs
Antipsychotics: antagonism of anti-Parkinsonian effect - avoid.
Metoclopramide: antagonism of anti-Parkinsonian effect - avoid.
Oestrogens: concentration increased.
[Metabolism]

Ropinirole is hepatically metabolised by the cytochrome P450 enzyme, CYP1A2, and excreted in the urine as inactive metabolites.
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