| Identification | Back Directory | [Name]
Elastase | [CAS]
9004-06-2 | [Synonyms]
ELA2
ELANE
elaszym
Eiastase
ELASTASE
Elastase-2
Elastase ES
e.c.3.4.4.7
EC 3.4.21.36
EC 3.4.21.37
LYSOSOMAL ELASTASE
elastolytic enzyme
pancre-atopeptidase
neutrophil elastase
ELASTASE, LEUKOCYTE
PANCREATOPEPTIDASE E
ELASTASE 2X-CRYSTALLIZED
ELASTASE, HUMAN NEUTROPHIL
macrophage metalloelastase
ELASTASE, HUMAN NEUTROPHILS
ELASTASE, NEUTROPHIL, HUMAN
Bone marrow serine protease
elastase from human leukocytes
fromporcinepancreaslyophilizedpowder
LEUKOCYTE ELASTASE, HUMAN NEUTROPHILS
Elastase from porcine pancreas, lyophil.
ELASTASE, LEUKOCYTE FROM HUMAN*LEUKOCYTE S
Elastase from human neutrophils min. 10 U/mg
3-(4-hydroxy-2,3-dimethoxy-phenyl)chroman-7-ol
ELASTASE FROM PORCINE PANCREAS LYOPHILIZED POWDER
Elastase froM huMan neutrophils Min. 10 U/Mg lyophil.
3-(4-hydroxy-2,3-dimethoxyphenyl)-3,4-dihydro-2H-chromen-7-ol
3-(4-hydroxy-2,3-dimethoxy-phenyl)-3,4-dihydro-2H-chromen-7-ol
ANTI-NEUTROPHIL ELASTASE(N-TERMINAL) antibody produced in rabbit
Elastasefromhumanneutrophils(whiteleucocytes),activity:18-30u/mgproteinsalt-free,lyophilizedsolid
ELASTASE FROM HUMAN NEUTROPHILS (WHITE LEUCOCYTES)ACTIVITY: 18-30 UNITS/MG PROTEIN SALT-FREE, LYOPHILIZED SOLID 98% BY SDS-PAGE | [EINECS(EC#)]
232-670-7 | [MDL Number]
MFCD00130997 |
| Hazard Information | Back Directory | [Uses]
Elastase from human leukocytes has been used:
- to measure serum elastase activity
- in proteolytic digestion of fibronectin and salivary glands
- in neutrophil elastase (NE) activity assay
- cell-free NE digestion of E-cadherin
- scratch wound assay
- in a study that determined that fragments of Nle3-angiotensin(1-7) accelerate healing in dermal models
Elastase has been used to digest fibronectin. The results were compared with fibronectin digestion by crude human leukocyte homogenate to examine the presence of fibronectin peptides in saliva of patients with Sj?gren′s syndrome. It has also been used as a reference to determine the elastase activity in cell lysates. This study examined the effect of all-trans retinoic acid on procoagulant and fibrinolytic activities of cultured blast cells. These blast cells were from patients with acute promyelocytic leukemia. | [General Description]
Elastase is a proteolytic enzyme. It is a member of the subgroup named, peptidyl peptide hydrolases. It is a major anatomic constituent of arteries. It is mainly found in the pancreas and pancreatic juice of various birds and mammals. It is also present in human serum, granulocytes and erythrocytes. | [Biochem/physiol Actions]
Elastase enzyme is capable of releasing soluble peptides from insoluble elastin fibers with the help of a proteolytic process. It can stimulate disintegration of the axoneme with the help of adenosine triphosphate (ATP). Unlike pancreatic elastase the leukocyte enzyme has a preferential cleavage for the carboxyl side of valine, but will also cleave to a lesser extent after alanine. Natural substrates include elastin, cartilage proteoglycans, collagen types I, II, II and IV, and fibronectin. |
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