| Identification | Back Directory | [Name]
mPEG8-Alkyne | [CAS]
880081-81-2 | [Synonyms]
mPEG8-Alkyne
mPEG11-Alkyne
MPEG8-PROPYNE
m-PEG8-O-alkyne
m-PEG9-Propargyl
2,5,8,11,14,17,20,23,26-Nonaoxanonacos-28-yne | [Molecular Formula]
C20H38O9 | [MDL Number]
MFCD31656935 | [MOL File]
880081-81-2.mol | [Molecular Weight]
422.51 |
| Hazard Information | Back Directory | [Biological Activity]
m-PEG8-O-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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