| Identification | Back Directory | [Name]
BMS-908662 | [CAS]
870603-16-0 | [Synonyms]
BMS-908662
BMS-908662(1X-281)
Carbamic acid, N-[6-[2-(5-chloro-2-methylphenyl)-2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl]-1H-benzimidazol-2-yl]-, methyl ester | [Molecular Formula]
C24H19ClN4O4 | [MOL File]
870603-16-0.mol | [Molecular Weight]
462.89 |
| Hazard Information | Back Directory | [Uses]
XL-281 (BMS-908662) is an orally active inhibitor for RAF kinase, with IC50s of 2.6, 4.5 and 6 nM, for CRAF, B-RAF, and B-RAFV600E, respectively. XL-281 exhibits antitumor activity[1]. | [IC 50]
c-Raf: 2.6 nM (IC50); B-Raf: 4.5 nM (IC50); B-RafV600E: 6 nM (IC50) | [References]
[1] Dickson MA, et al., Phase I study of XL281 (BMS-908662), a potent oral RAF kinase inhibitor, in patients with advanced solid tumors. Invest New Drugs. 2015 Apr;33(2):349-56. DOI:10.1007/s10637-014-0191-5 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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