| Identification | More | [Name]
Diphenylacetonitrile | [CAS]
86-29-3 | [Synonyms]
BENZHYDRYL CYANIDE
DIPAN
DIPHENATRILE
DIPHENYLACETONITRILE
DIPHENYL-A-CYANOMETHANE
DIPHENYLMETHYL CYANIDE
RARECHEM AQ A3 0160
Acetonitrile, diphenyl-
alpha-Cyanodiphenylmethane
alpha-phenyl-benzeneacetonitril
alpha-phenylbenzeneacetonitrile
alpha-Phenyl-benzeneacetonitrile
alpha-Phenylbenzylcyanide
alpha-Phenylphenylacetonitrile
a-Phenylbenzyl cyanide
a-Phenylphenylacetonitrile
Benzyhydrylcyanide
-Cyanodiphenylmethane
dibenzylcyanide
Difenylacetonitril | [EINECS(EC#)]
201-662-5 | [Molecular Formula]
C14H11N | [MDL Number]
MFCD00001862 | [Molecular Weight]
193.24 | [MOL File]
86-29-3.mol |
| Chemical Properties | Back Directory | [Appearance]
white to creamy or faint yellow crystalline powder | [Melting point ]
71-73 °C (lit.) | [Boiling point ]
181 °C/12 mmHg (lit.) | [density ]
1.1061 (rough estimate) | [vapor pressure ]
21.3 hPa (190 °C) | [refractive index ]
1.5850 (estimate) | [Fp ]
120 °C
| [storage temp. ]
Store below +30°C. | [solubility ]
INSOLUBLE | [form ]
Crystalline Powder | [color ]
White to creamy or faint yellow | [Water Solubility ]
INSOLUBLE | [Merck ]
14,3316 | [BRN ]
1911160 | [Exposure limits]
NIOSH: IDLH 25 mg/m3 | [InChIKey]
NEBPTMCRLHKPOB-UHFFFAOYSA-N | [LogP]
2.795-3.197 at 25℃ | [CAS DataBase Reference]
86-29-3(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzeneacetonitrile, «alpha»-phenyl-(86-29-3) | [EPA Substance Registry System]
86-29-3(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
2
| [RTECS ]
AL9800000
| [TSCA ]
Yes | [HS Code ]
29269095 | [Safety Profile]
Poison by ingestion,
intraperitoneal, and intravenous routes.
Moderately toxic by subcutaneous route.
Questionable carcinogen with experimental
carcinogenic and tumorigenic data. When
heated to decomposition it emits toxic
fumes of NOx, and CN-. See also
NITRILES. | [Toxicity]
LD50 orally in Rabbit: 3500 mg/kg |
| Hazard Information | Back Directory | [Description]
Diphenatril (Diphenylacetonitrile) has another name called the alpha-cyano ditane, White crystals, fusing point is 76 ℃, is dissolved in ethanol, ether.Diphenatril is of many uses.Can make weedicide, be used for turf before the bud, can prevent and kill off Gramineae children grass; Industry for the synthesis of isocyanic ester, further is prepared into UV coating, PU lacquer, transparent elastomer and tackiness agent etc. as organic synthesis intermediate, in addition, also is applied to the industrial circles such as polymeric amide and Resins, epoxy; Aspect medical, diphenatril is commonly used to produce the medicines such as stomach amine, diphenoxylate, the loose pain of class.It is important pharmaceutical-chemical intermediate. | [Chemical Properties]
white to creamy or faint yellow crystalline powder | [Uses]
Mathadone (M225865) impurity. | [Application]
Diphenylacetonitrile can be prepared in good yield by the dehydration of the amide of diphenyl acetic acid with phosphorous oxychloride. Diphenylacetonitrile undergoes anhydrous condensation with ethyl-4-bromo-butyrate. This is followed by its hydrolysis in alkaline medium that is used in the quantitative determination of 3-cyano-3,3-diphenylpropionic acid. | [Application]
Diphenylacetonitrile undergoes anhydrous condensation with ethyl-4-bromo-butyrate. This is followed by its hydrolysis in alkaline medium that is used in the quantitative determination of 3-cyano-3,3-diphenylpropionic acid. | [Preparation]
Diphenylacetonitrile can be prepared in good yield by the dehydration of the amide of diphenyl acetic acid with phosphorous oxychloride. | [Reactions]
Methadone is synthesised by alkylation of diphenylacetonitrile using 2-dimethylaminopropylchloride in the presence of sodamide.
Dextromoramide is synthesised by alkylation of diphenylacetonitrile using 1-morpholinyl-2- chloropropane in the presence of sodamide.
Diphenylacetonitrile in the presence of sodium amide is alkylated with 1-ethyl-3-chlorpyrrolidine, giving (1-ethyl-3-pyrrolidinyl) diphenylacetonitrile.
Isopropamide, is synthesized by alkylating diphenylacetonitrile with di-isopropylaminoethylchloride in the presence of sodium amide, and the subsequent hydrolysis of the nitrile group of the resulting compound to an amide group. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 35, p. 3253, 1970 DOI: 10.1021/jo00835a016 | [General Description]
Diphenylacetonitrile can be prepared in good yield by the dehydration of the amide of diphenyl acetic acid with phosphorous oxychloride. | [Synthesis]
Add the 250mL ethyl acetate in 500mL glass there-necked flask, open and stir, add the 150g phenylcarbinol, add sodium methylate 80g, 70 ℃ of stirring reactions 2 hours are down to room temperature, add benzyl cyanide 120ml.Be heated to 110 ℃, distillation reaction 10h.Reaction naturally cools to room temperature after finishing, and adds the extraction of 200ml ethyl acetate and 200ml water, tells lower aqueous layer.The upper strata ethyl acetate layer adds water, and washing once adds anhydrous sodium sulfate drying.Concentrating under reduced pressure is removed ethyl acetate.Then in oily matter, add a small amount of dehydrated alcohol crystallisation by cooling, the crystallized product oven dry.Yield 90%, purity 99.0% (GC). | [Purification Methods]
Crystallise the nitrile from EtOH or pet ether (b 90-100o). [Beilstein 9 H 674, 9 IV 2505.] |
|
|