| Identification | More | [Name]
Nafamostat mesylate | [CAS]
82956-11-4 | [Synonyms]
6-AMIDINO-2-NAPHTHYL-4-GUANIDINOBENZOATE DIMETHANESULFONATE
6-amidino-2-naphthyl 4-guanidino-benzoate dimethanesulphonate
6-AMIDINO-2-NAPHTHYL-4-GUANIDINOENZOATE, MESYLATE
FUT-175
FUTHAN
NAFAMOSTAT MESYLATE
4-((aminoiminomethyl)amino)-benzoicaci6-(aminoiminomethyl)-2-naphthalenyl
ester,dimethanesulfonate
nafamstatmesilate
FUT-175,6-Amidino-2-naphthyl-4-guanidinoenzoate,mesylate
Nafomastatmesilate
FUT-175, 4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate
4-Guanidinobenzoic acid 6-amidino-2-naphtyl·2(methanesulfonic acid)
Nafamstat mesylate | [EINECS(EC#)]
692-168-2 | [Molecular Formula]
C21H25N5O8S2 | [MDL Number]
MFCD00941430 | [Molecular Weight]
539.58 | [MOL File]
82956-11-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Tan to pale orange solid | [Melting point ]
259-261°C | [storage temp. ]
Room temp | [solubility ]
Soluble in Water (up to 25 mg/ml). | [form ]
powder | [color ]
white to beige | [Usage]
A non-peptide proteaseinhibitor | [Merck ]
14,6350 | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at 4°C for up to 1 month, or at -80°C for up to 6 months. | [InChIKey]
SRXKIZXIRHMPFW-UHFFFAOYSA-N | [SMILES]
CS(O)(=O)=O.CS(O)(=O)=O.C(OC1=CC=C2C(=C1)C=CC(C(=N)N)=C2)(=O)C1=CC=C(NC(N)=N)C=C1 | [CAS DataBase Reference]
82956-11-4(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
Nafamostat mesylate(cas82956-11-4) is a protease inhibitor useful in the treatment of acute pancreatitis. It has anticomplement,
anticoagulant, antikallikrein and other activities, and thus may have additional
utility in the treatment of autoimmune diseases and disseminated intravascular coagulation.
| [Chemical Properties]
Tan to pale orange solid | [Originator]
Torii (Japan) | [Uses]
A non-peptide proteaseinhibitor | [Uses]
Nafamostat is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma | [Brand name]
FUTHAN | [Biological Activity]
Broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. | [Biochem/physiol Actions]
Nafamostat mesylate is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation. It is also a possible complement inhibitor. | [Synthesis]
By p-guanidinobenzoic acid hydrochloride, 6-amidino groups-beta naphthal, 4,5-dicyano imidazole, methylene dichloride mix, 0-5 ℃ is stirred 1 hour, then improve temperature to 18-22 ℃, insulation reaction 8-12h, filters washed with dichloromethane, gained solid is 2 with methylsulfonic acid adjust pH, obtains nafamostat mesylate. | [storage]
Store at +4°C | [References]
1) Han et al. (2019) Identification of nafamostat mesilate as an inhibitor of the fat mass and obesity-associated protein (FTO) demethylase; Chem. Biol. Interact., 297 80 |
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