| Identification | Back Directory | [Name]
NAFAMOSTAT MESYLATE | [CAS]
81525-10-2 | [Synonyms]
FUTHAN
FUT-175
Nafamstat
NAFAMOSTAT
NAFAMOSTAT MESILATE
Mesylate nafaMostat
NafamostatMesilateBase
Nafamostat Dimethanesulfonate
6-Amidino-2-naphthyl 4-guanidinobenzoate
6-AMIDINO-2-NAPHTHYL-4-GUANIDINOENZOATE, MESYLATE
4-Guanidinobenzoic acid 6-amidino-2-naphtyl ester
4-(Amidinoamino)benzoic acid 6-amidino-2-naphtyl ester
6-AMIDINO-2-NAPHTHYL-4-GUANIDINOBENZOATE DIMETHANESULFONATE
Benzoic acid, 4-[(aMinoiMinoMethyl)aMino]-, 6-(aMinoiMinoMethyl)-2-naphthalenyl ester | [EINECS(EC#)]
1806241-263-5 | [Molecular Formula]
C21H25N5O8S2 | [MDL Number]
MFCD00941430 | [MOL File]
81525-10-2.mol | [Molecular Weight]
539.58 |
| Chemical Properties | Back Directory | [Boiling point ]
586.0±60.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
11.30±0.30(Predicted) |
| Hazard Information | Back Directory | [Chemical Properties]
Odorless, bitter taste. Easily soluble in water, insoluble in methanol, ethanol or dimethylformamide, almost insoluble in ether, chloroform or acetone. Density: 1.39g/cm3; Boiling Point: 637.2°C; Flash Point: 339.1°C; Vapor Pressure: 3.9E-16mmHg. | [Uses]
Nafamostat is a non-peptide synthetic protease inhibitor with broad-spectrum and potent enzyme inhibition. For the treatment of acute pancreatitis. It can improve acute symptoms of acute pancreatitis, acute exacerbation of chronic pancreatitis, and post-traumatic pancreatitis. | [Definition]
ChEBI: Nafamostat is a member of benzoic acids and a member of guanidines. | [Preparation]
6-Bromo-2-naphthol reacts with copper cyanide in dimethylformamide to generate 6-cyano-2-naphthol, which is methanolylated and then aminolyzed to generate 6-amidino-2-naphthol , and finally esterification with p-guanidinobenzoic acid to generate nafamostat. | [storage]
Store at -20°C |
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