| Identification | More | [Name]
Ethyl 2-hydroxyisobutyrate | [CAS]
80-55-7 | [Synonyms]
2-HYDROXYISOBUTYRIC ACID ETHYL ESTER
2-METHYLLACTIC ACID ETHYL ESTER
ETHYL 2-HYDROXY-2-METHYLPROPIONATE
ETHYL 2-HYDROXYISOBUTYRATE
ETHYL 2-METHYLLACTATE
ETHYL-ALPHA-HYDROXY-ISO-BUTYRATE
Ethyl hydroxyisobutyrate
2-hydroxy-2-methyl-propanoicaciethylester
2-hydroxyisobutyricacidethylester(alpha-)
2-methyl-lacticaciethylester
Ethyl 2-hydroxy-2-methylpropanoate
ethyl2-hydroxy-2-methylpropanoate
Lactic acid, 2-methyl-, ethyl ester
Ethyl 2-hydroxy-2-methylpropionate~Ethyl 2-methyllactate~2-Hydroxyisobutyric acid ethyl ester
Ethyl hydroxyisobtyrate
Ethyl(Methyl)2-hydroxyisobutyrate
Ethyl-a-hydroxy-iso-butyrate
Propanoic acid, 2-hydroxy-2-methyl-, ethyl ester
Methyllactic acid ethyl ester, 2-: (Ethyl 2-hydroxyisobutyrate)
Ethyl 2-methyl-2-hydroxypropanoate | [EINECS(EC#)]
201-290-3 | [Molecular Formula]
C6H12O3 | [MDL Number]
MFCD00004458 | [Molecular Weight]
132.16 | [MOL File]
80-55-7.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless liquid | [Melting point ]
78 °C | [Boiling point ]
150 °C (lit.) | [density ]
0.965 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.408(lit.)
| [Fp ]
112 °F
| [storage temp. ]
Flammables area | [form ]
clear liquid | [pka]
13.28±0.29(Predicted) | [color ]
Colorless to Almost colorless | [BRN ]
878308 | [InChI]
InChI=1S/C6H12O3/c1-4-9-5(7)6(2,3)8/h8H,4H2,1-3H3 | [InChIKey]
GFUIDHWFLMPAGY-UHFFFAOYSA-N | [SMILES]
C(OCC)(=O)C(O)(C)C | [Uses]
Solvent for nitrocellulose and cellulose acetate; solvent mixture for cellulose ethers, organic synthesis, pharmaceuticals. | [CAS DataBase Reference]
80-55-7(CAS DataBase Reference) | [NIST Chemistry Reference]
Propanoic acid, 2-hydroxy-2-methyl-, ethyl ester(80-55-7) | [EPA Substance Registry System]
80-55-7(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R10:Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin .
R36/38:Irritating to eyes and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 3272 3/PG 3
| [WGK Germany ]
3
| [RTECS ]
OD5672000
| [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29181980 |
| Hazard Information | Back Directory | [Description]
Ethyl 2-hydroxyisobutyrate (E-2HIBA) has a wide range of applications in flavor and fragrance ingredients, green solvents, and pharmaceuticals. E-2HIBA has been synthesized by the batch transesterification of methyl 2-hydroxyisobutyrate with ethanol in the presence of titanium tetraethoxide (reaction conditions: 96 h, yield 97 %) and the esterification of 2-HIBA with an acid catalyst. The direct esterification of 2-HIBA with ethanol using an acid catalyst appears to be a commercially viable approach to produce E-2HIBA [1].
| [Chemical Properties]
clear colorless liquid | [References]
[1] Sripada, Sarada and James R. Kastner. “Continuous catalytic esterification using a solid acid activated carbon monolith: Comparison of granular and monolith forms with a commercial catalyst.” Chemical Engineering Journal 43 29 (2023): 0.
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