| Identification | Back Directory | [Name]
D-AP5 | [CAS]
79055-68-8 | [Synonyms]
D-AP5
D-APV
IF4G2
EIF4G2
(R)-AP-5
Death associated protein 5
(R)-2-Amino-5-phosphonovaleric acid
(R)-5-Phosphono-2-aminovaleric acid
D-2-AMINO-5-PHOSPHONOPENTANOIC ACID
(2R)-2-Amino-5-phosphonovaleric acid
D(-)-2-AMINO-5-PHOSPHONOPENTANOIC AC
(R)-2-aMino-5-phosphonopentanoic acid
D-(-)-2-AMINO-5-PHOSPHONOVALERIC ACID
(2R)-2-aMMonio-5-phosphonatopentanoate
D-(-)-2-AMINO-5-PHOSPHONOPENTANOIC ACID
D(-)-2-Amino-5-phosphonovaleric acid hydrate
D(-)-2-Amino-5-phosphonovaleric acid (D-AP5)
Eukaryotic translation initiation factor 4 γ 2
D-(-)-2-AMINO-5-PHOSPHONOPENTANOIC ACID (D-AP5)
Anti-EIF4G2, N-Terminal antibody produced in rabbit
D(-)-AP-5, D(-)-APV, D-2-Amino-5-phosphonovaleric acid
D(-)-2-Amino-5-phosphonovaleric acid hydrate,96%, (>98% ee) | [Molecular Formula]
C5H12NO5P | [MDL Number]
MFCD00078839 | [MOL File]
79055-68-8.mol | [Molecular Weight]
197.13 |
| Chemical Properties | Back Directory | [Appearance]
white fine crystalline powder | [Melting point ]
approximate 233℃ | [Boiling point ]
482.1±55.0 °C(Predicted) | [density ]
1.529±0.06 g/cm3(Predicted) | [RTECS ]
RD2513000 | [storage temp. ]
Store at RT | [solubility ]
Soluble to 100 mM in sterile | [form ]
White solid | [pka]
2.46±0.10(Predicted) | [color ]
White | [Water Solubility ]
Soluble in water (100mM) | [Sensitive ]
Light Sensitive |
| Hazard Information | Back Directory | [Description]
D-AP5 is a selective N-methyl-D-aspartate (NMDA) receptor antagonist (Kd = 1.4 μM) that competitively inhibits the glutamate binding site of NMDA receptors.1 Whereas D-AP5 is the active (−)-stereoisomer, its (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity.1 AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.2 | [Chemical Properties]
white fine crystalline powder | [Uses]
A competitive NMDA antagonist | [General Description]
Active enantiomer of DL-2-amino-5-phosphonopentanoic acid (AP5) that is a commonly used competitive NMDA receptor antagonist. | [Biological Activity]
Widely used competitive NMDA antagonist. More active form of AP5. Also agonist at quisqualate-sensitized AP6 site where it is less potent than the L-isomer (L-(+)-2-Amino-5-phosphonopentanoic acid ). Also available as part of the Mixed NMDA Receptor Tocriset™ . | [Biochem/physiol Actions]
Product does not compete with ATP. | [storage]
Store at -20°C |
|
| Company Name: |
|
| Tel: |
821-50328103-801 18930552037 |
| Website: |
http://m.is0513.com/ShowSupplierProductsList13285/0.htm |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|