| Identification | More | [Name]
DIISOPROPYLDICHLOROSILANE | [CAS]
7751-38-4 | [Synonyms]
DICHLORODIISOPROPYSILANE
DIISOPROPYLDICHLOROSILANE
DICHLORODIISOPROPYLSILANE
dichlorodiisopropylisilane
Dichlorodiisopropylsilane>
dichloro-di(propan-2-yl)silane
Silane, dichlorobis(1-methylethyl)-
Dichlorodiisopropylsilane >=97.0% (GC)
Diisopropyldichlorosilane, 97%, for synthesis | [Molecular Formula]
C6H14Cl2Si | [MDL Number]
MFCD00054895 | [Molecular Weight]
185.17 | [MOL File]
7751-38-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
<0°C | [Boiling point ]
66 °C27 mm Hg(lit.) | [density ]
1.026 g/mL at 20 °C(lit.)
| [refractive index ]
n20/D 1.444
| [Fp ]
43°C | [solubility ]
sol most organic solvents. | [form ]
clear liquid | [color ]
Colorless to Light yellow to Light orange | [Specific Gravity]
1.026 | [Hydrolytic Sensitivity]
8: reacts rapidly with moisture, water, protic solvents | [BRN ]
1736244 | [CAS DataBase Reference]
7751-38-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R10:Flammable.
R34:Causes burns. | [Safety Statements ]
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2986 8/PG 2
| [WGK Germany ]
3
| [F ]
10-21 | [TSCA ]
No | [HazardClass ]
3/8 | [PackingGroup ]
II | [HS Code ]
29319090 |
| Hazard Information | Back Directory | [Physical properties]
bp 50–55°C/5 mmHg. | [Uses]
Dichlorodiisopropylsilane can be used in nucleoside 3',5'-hydroxy protection; component in Peterson
alkenation reaction.
The use of silicon groups as
protection for hydroxy groups has been widely exploited.3 One
potentially useful way to protect a nucleoside is by using a protecting
group which spans the 3- and 5-hydroxy groups. One of
the useful groups which can be used as a bifunctional protecting
group in nucleosides is the diisopropylsilyl group. Reaction of the
nucleoside with dichlorodiisopropylsilane and imidazole in DMF
gives the protected nucleoside (eq 1).This method has not been widely used; the more common 3',5'-hydroxy-bridging protecting
group is a tetraisopropyldisiloxy group.
| [Preparation]
conveniently prepared by the reaction of diisopropylsilane
in carbon tetrachloride with palladium(II) chloride
at 140°C for 8 h in a steel bomb.Washing the residue with
ether and removing the ether by rotary evaporation yields the
product which is purified by distillation to yield a clear colorless
oil. |
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