| Identification | More | [Name]
3',4'-DIHYDROXYPROPIOPHENONE | [CAS]
7451-98-1 | [Synonyms]
3',4'-DIHYDROXYPROPIOPHENONE
3,4-DIHYDROXYPROPIOPHENONE
1-(3,4-dihydroxyphenyl)-1-propanon
3’,4’-dihydroxy-propiophenon
3',4'-Dihydroxypropiophenone,98%
1-(3,4-dihydroxyphenyl)propan-1-one
1-(3,4-Dihydroxyphenyl)-1-propanone | [Molecular Formula]
C9H10O3 | [MDL Number]
MFCD00016440 | [Molecular Weight]
166.17 | [MOL File]
7451-98-1.mol |
| Hazard Information | Back Directory | [Uses]
It is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. | [Preparation]
Obtained by Fries rearrangement of pyrocatechol dipropio-nate with aluminium chloride in chlorobenzene at 80° for 2 h (84%) or in nitrobenzene at 100° for 15 min;
Obtained by Fries rearrangement of pyrocatechol dipropionate with aluminium chloride in the presence of pyrocatechol, in nitrobenzene at 80° for 1 h (37%) or in nitromethane at r.t. for 72 h (76%)
Also obtained by Fries rearrangement of o-methoxyphenyl propionate (1 mol) by aluminium chloride (2 mol) without solvent at 140° for 2 h (51–55%) or in nitrobenzene at 80° for 30–60 min. A demethylation occurs during the reaction.
Also obtained by acylation of pyrocatechol with propionic acid
in the presence of boron trifluoride, at 150° for 2 h in a sealed tube ? (36%)
in the presence of polyphosphoric acid for 15 min in a boiling water bath ? (12%)
Preparation by demethylation of 4-hydroxy-3-methoxypropiophenone with refluxing pyridinium chloride for 10 min (80%)
Also obtained when propiovanillone was heated with an alkali sulfide under conditions used in the kraft cooking process. |
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