| Identification | More | [Name]
2-Fluoro-5-nitrobenzoic acid | [CAS]
7304-32-7 | [Synonyms]
2-FLUORO-5-NITROBENZOIC ACID
BUTTPARK 32\01-76
RARECHEM AL BO 0445
2-Fluoro-5-nitrobenzoic acid 98%
2-Fluoro-5-nitrobenzoicacid98%
2-FLUORO-5-NITRROBENZOIC ACID
2-Fluoro-5-nitrobenzotc acid | [EINECS(EC#)]
627-772-7 | [Molecular Formula]
C7H4FNO4 | [MDL Number]
MFCD00134238 | [Molecular Weight]
185.11 | [MOL File]
7304-32-7.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powder | [Melting point ]
142-144 °C (lit.) | [Boiling point ]
337.7±27.0 °C(Predicted) | [density ]
1.568±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Soluble in chloroform, ethanol. | [form ]
Crystalline Powder | [pka]
2.54±0.10(Predicted) | [color ]
White to pale yellow | [BRN ]
1912835 | [CAS DataBase Reference]
7304-32-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29163990 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powder | [Uses]
2-Fluoro-5-nitrobenzoic acid may be used in the synthesis of:
- dibenz[b,f]oxazepin-11(10H)-ones, via the nucleophilic aromatic substitution (SNAr) of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH of various 2-aminophenols on solid support
- synthesis of substituted dibenzazocines on solid support, via SNAr of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH function of the immobilized polysubstituted phenols
- in the synthesis of oxazepines
| [Uses]
2-Fluoro-5-nitrobenzoic acid may be used in the synthesis of dibenz[b,f]oxazepin-11(10H)-ones, via the nucleophilic aromatic substitution (SNAr) of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH of various 2-aminophenols on solid support, synthesis of substituted dibenzazocines on solid support, via SNAr of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH function of the immobilized polysubstituted phenols, in the synthesis of oxazepines. | [General Description]
2-Fluoro-5-nitrobenzoic acid is reported to react with an aldehyde, isonitrile and a primary amine tethered to a Boc-protected internal amino or hydroxyl nucleophile, to afford the Ugi product. |
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