| Identification | More | [Name]
2-Bromoacetophenone | [CAS]
70-11-1 | [Synonyms]
2-BROMO-1-PHENYL-1-ETHANONE
2-BROMO-1-PHENYLETHANONE
2-BROMOACETOPHENONE
A-BROMOACETOPHENONE
AKOS BBS-00004003
ALPHA-BROMOACETOPHENONE
OMEGA-BROMOACETOPHENONE
PHENACYL BROMIDE
TIMTEC-BB SBB002705
2-Bromo-1-phenyethanone
2-bromo-1-phenyl-ethanon
Acetophenone, 2-bromo-
Benzoylmethyl bromide
-Bromoacetophenone
Bromomethyl phenyl ketone
Bromomethylphenylketone
Ethanone,2-bromo-1-phenyl-
Ethanone2-bromo-1-phenyl-
omega-Bromacetophenone
Stauffer 4644 | [EINECS(EC#)]
200-724-9 | [Molecular Formula]
C8H7BrO | [MDL Number]
MFCD00000195 | [Molecular Weight]
199.04 | [MOL File]
70-11-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Off white-grey green crystaline powder | [Melting point ]
48-51 °C (lit.) | [Boiling point ]
135 °C/18 mmHg (lit.) | [density ]
1.476 | [refractive index ]
1.5700 (estimate) | [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Crystals or Powder | [color ]
White to dark green-brown | [Stability:]
Stable. Incompatible with strong bases, strong oxidizing agents. Combustible. | [Water Solubility ]
PRACTICALLY INSOLUBLE | [Merck ]
14,1402 | [BRN ]
606474 | [InChIKey]
LIGACIXOYTUXAW-UHFFFAOYSA-N | [CAS DataBase Reference]
70-11-1(CAS DataBase Reference) | [NIST Chemistry Reference]
Ethanone, 2-bromo-1-phenyl-(70-11-1) | [EPA Substance Registry System]
70-11-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2645 6.1/PG 2
| [WGK Germany ]
3
| [F ]
8-19 | [Hazard Note ]
Corrosive | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
II | [HS Code ]
29147000 |
| Hazard Information | Back Directory | [General Description]
A crystalline solid or a liquid with a sharp odor. Toxic by inhalation, ingestion and skin absorption. A severe eye irritant (a lachrymator). Used to make other chemicals. | [Reactivity Profile]
PHENACYL BROMIDE(70-11-1) reacts slowly with metals causing mild corrosion. | [Air & Water Reactions]
Reacts slowly with moisture in air to form hydrogen bromide. | [Health Hazard]
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. | [Fire Hazard]
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. | [Chemical Properties]
Off white-grey green crystaline powder | [Uses]
2-Bromoacetophenone is a brominated acteophenone derivative. 2-Bromoacetophenone has been shown to completely and irreversibly inactivate human liver aldehyde dehydrogenase (EC 1.2.1.3) isoenzymes E1
and E2. 2-Bromoacetophenone and its derivatives display some inhibitory activity on neutral protein tyrosine.inhibitors | [Uses]
Preparation of crystalline esters from acids | [Definition]
ChEBI: An alpha-bromoketone that is acetophenone substituted by a bromo group at position 2. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 76, p. 5796, 1954 DOI: 10.1021/ja01651a061
Organic Syntheses, Coll. Vol. 2, p. 480, 1943
Synthetic Communications, 22, p. 1923, 1992 DOI: 10.1080/00397919208021322 | [Purification Methods]
Crystallise the bromide from EtOH, MeOH or pet ether (b 80-100o). [Tanner J Org Chem 52 2142 1987, Beilstein 7 IV 649.] |
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